FastER: Identification of genes with fast-evolving regions in closely related genomes
Yu Zheng, Rich Roberts & Simon Kasif
Bioinformatics Graduate Program, Boston University
FastER is a software for identifying orthologous gene pairs that appear to have fast-evolving regions between two closely related genomes. Its input can be either two closely related whole genome sequences or two closely related orthologous sequences. It consists of two steps: first, it will detect all regions with overrepresented nonsynonymous mutations; second, it will test the nonsynonymous evolution rate against the neutral evolution rate in that gene. The full system IS Described in the paper(link).
You can download Faster v1.0(updated 7/29/05) and run it. A set of preinstalled PERL packages are necessary. Download clustalW.
Please address questions on installation to: firstname.lastname@example.org
Copyright©Yu Zheng 2004