| GenBank ID | Current annotation |
| 6319783 | Permease of basic amino acids in the vacuolar membrane |
| 10383753 | catabolism of hydroxy amino acids; catabolic serine (threonine) dehydratase |
| 6319793 | Zinc metalloendopeptidase, found in the cytoplasm and intermembrane space of mitochondria |
| 6319796 | AdoMet-dependent methyltransferase involved in rRNA processing and 60S ribosomal subunit maturation; methylates G2922 in the putative tRNA docking site of the large subunit rRNA and in the absence of snR52, U2921; suppressor of PAB1 mutants |
| 6319806 | Protein disulfide isomerase, multifunctional protein resident in the endoplasmic reticulum lumen, essential for the formation of disulfide bonds in secretory and cell-surface proteins, unscrambles non-native disulfide bonds |
| 10383761 | Multifunctional enzyme containing phosphoribosyl-ATP pyrophosphatase, phosphoribosyl-AMP cyclohydrolase, and histidinol dehydrogenase activities; catalyzes the second, third, ninth and tenth steps in histidine biosynthesis |
| 10383767 | Protein kinase of the bud neck involved in the septin checkpoint, associates with septin proteins, negatively regulates Swe1p by phosphorylation, shows structural homology to bud neck kinases Gin4p and Hsl1p |
| 10383770 | TyB Gag-Pol protein; proteolytically processed to make the Gag, RT, PR, and IN proteins that are required for retrotransposition |
| 10383773 | Cysteine desulfurase involved in iron-sulfur cluster (Fe/S)biogenesis; required for the post-transcriptional thio-modification of mitochondrial and cytoplasmic tRNAs; essential protein located predominantly in mitochondria |
| 42759852 | Component of the ESCRT-I complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome; homologous to the mouse and human Tsg101 tumor susceptibility gene; mutants exhibit a Class E Vps phenotype |
| 10383778 | Phosphatidylglycerolphosphate synthase, catalyzes the synthesis of phosphatidylglycerolphosphate from CDP-diacylglycerol and sn-glycerol 3-phosphate in the first committed and rate-limiting step of cardiolipin biosynthesis |
| 6319850 | Citrate synthase, catalyzes the condensation of acetyl coenzyme A and oxaloacetate to form citrate, peroxisomal isozyme involved in glyoxylate cycle; expression is controlled by Rtg1p and Rtg2p transcription factors |
| 6319853 | Protein with similarity to Npr1p protein kinase; Ser/Thr protein kinase |
| 10383780 | Putative ATP-dependent permease of the ABC transporter family of proteins |
| 6319872 | Mitochondrial asparaginyl-tRNA synthetase |
| 6319876 | Plasma membrane H+-pantothenate symporter; confers sensitivity to the antifungal agent fenpropimorph |
| 10383797 | Putative ribokinase |
| 10383798 | Low-affinity inorganic phosphate (Pi) transporter, involved in activation of PHO pathway; expression is independent of Pi concentration and Pho4p activity; contains 12 membrane-spanning segments |
| 6319893 | Hypothetical ORF |
| 6319896 | Acyl-CoA |
| 6319901 | threonine synthase |
| 6319903 | Conserved 90S pre-ribosomal component essential for proper endonucleolytic cleavage of the 35 S rRNA precursor at A0, A1, and A2 sites; contains eight WD-repeats; PWP2 deletion leads to defects in cell cycle and bud morphogenesis |
| 6319904 | piecemeal microautophagy of the nucleus (PMN) |
| 10383804 | Protein required for cell viability |
| 10383805 | functionally redundant with, and homologous to, SSK2; protein kinase |
| 6319926 | General repressor of transcription (with Cyc8p), mediates glucose repression; exhibits similarity to beta subunits of G proteins |
| 10383810 | Putative serine/threonine protein kinase, most similar to cyclic nucleotide-dependent protein kinase subfamily and the protein kinase C subfamily |
| 6319935 | Mismatch repair protein, forms dimers with Msh2p that mediate repair of insertion or deletion mutations and removal of nonhomologous DNA ends, contains a PCNA (Pol30p) binding motif required for genome stability |
| 10383811 | Component of the CCR4-NOT complex, which has multiple roles in regulating mRNA levels including regulation of transcription and destabilizing mRNAs by deadenylation; basal transcription factor |
| 6319941 | Plasma membrane permease, mediates uptake of the phosphatidylinositol metabolite glycerophosphoinositol as a source of the nutrients inositol and phosphate; expression and transport rate are regulated by phosphate and inositol availability |
| 6319949 | NADPH-dependent cinnamyl alcohol dehydrogenase family member with broad substrate specificity; may be involved in fusel alcohol synthesis |
| 6319951 | Putative aryl-alcohol dehydrogenase with similarity to P. chrysosporium aryl-alcohol dehydrogenase; mutational analysis has not yet revealed a physiological role |
| 6319355 | Hypothetical ORF |
| 6319363 | Protein serine/threonine kinase essential for cell wall remodeling during growth; localized to sites of polarized growth and the mother-daughter bud neck; homolog of the alpha, beta, and gamma isoforms of mammalian protein kinase C (PKC) |
| 6319369 | TyB Gag-Pol protein; proteolytically processed to make the Gag, RT, PR, and IN proteins that are required for retrotransposition |
| 41629672 | Essential protein required for chromosome condensation, likely to function as an intrinsic component of the condensation machinery, may influence multiple aspects of chromosome transmission and dynamics |
| 6319387 | Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition |
| 6319391 | Protein required for mitochondrial translation; mutation is functionally complemented by a Bacillus subtilis ortholog |
| 6319395 | Cytoplasmic isoleucine-tRNA synthetase, target of the G1-specific inhibitor reveromycin A |
| 50593116 | Putative ubiquitin-specific protease |
| 6319408 | Kinesin-related motor protein required for mitotic spindle assembly and chromosome segregation; functionally redundant with Cin8p |
| 6319413 | UBX (ubiquitin regulatory X) domain-containing protein that regulates Glc7p phosphatase activity and interacts with Cdc48p; interacts with ubiquitylated proteins in vivo and is required for degradation of a ubiquitylated model substrate |
| 6319415 | Type 2C protein phosphatase; dephosphorylates Hog1p (see also Ptc2p) to limit maximal kinase activity induced by osmotic stress; dephosphorylates T169 phosphorylated Cdc28p (see also Ptc2p); role in DNA checkpoint inactivation |
| 6319426 | Core subunit of the ubiquinol-cytochrome c reductase complex (bc1 complex), which is a component of the mitochondrial inner membrane electron transport chain |
| 6319434 | clathrin Associated Protein complex Large subunit; Large subunit of clathrin associated protein complex |
| 6319447 | S-adenosyl-L-methionine-dependent tRNA |
| 6319448 | Protein involved in DNA replication; component of the Mcm2-7 hexameric complex that binds chromatin as a part of the pre-replicative complex |
| 6319449 | Mitochondrial ATP-dependent protease involved in intramitochondrial proteolysis; involved in degradation of misfolded proteins in mitochondria; required for bigenesis and maintenance of mitochondria |
| 6319463 | Non-essential transcriptional corepressor involved in the cell cycle-regulated transcription of histone H2A, H2B, H3 and H4 genes; contributes to nucleosome formation, heterochromatic gene silencing, and formation of functional kinetochores |
| 6319468 | TyB Gag-Pol protein; proteolytically processed to make the Gag, RT, PR, and IN proteins that are required for retrotransposition |
| 6319486 | TyB Gag-Pol protein; proteolytically processed to make the Gag, RT, PR, and IN proteins that are required for retrotransposition |
| 6319491 | Transportin, cytosolic karyopherin beta 2 involved in delivery of heterogeneous nuclear ribonucleoproteins to the nucleoplasm, binds rg-nuclear localization signals on Nab2p and Hrp1p, plays a role in cell-cycle progression |
| 6319497 | Chitin synthase III, catalyzes the transfer of N-acetylglucosamine (GlcNAc) to chitin; required for synthesis of the majority of cell wall chitin, the chitin ring during bud emergence, and spore wall chitosan |
| 6319498 | Protein anchored to the mitochondrial inner membrane, similar to Sco1p and may have a redundant function with Sco1p in delivery of copper to cytochrome c oxidase; interacts with Cox2p |
| 6319502 | Hypothetical ORF |
| 6319511 | Copper-binding protein of the mitochondrial inner membrane, required for cytochrome c oxidase activity and respiration; may function to deliver copper to cytochrome c oxidase; has similarity to thioredoxins |
| 6319512 | Chitin synthase II, requires activation from zymogenic form in order to catalyze the transfer of N-acetylglucosamine (GlcNAc) to chitin; required for the synthesis of chitin in the primary septum during cytokinesis |
| 6319513 | Gamma subunit of the F1 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis |
| 41629676 | Fatty acid transporter and very long-chain fatty acyl-CoA synthetase, may form a complex with Faa1p or Faa4p that imports and activates exogenous fatty acids |
| 6319516 | Hypothetical ORF |
| 6319517 | Multidrug transporter required for resistance to quinidine, barban, cisplatin, and bleomycin; member of the major facilitator superfamily of transporters conferring multiple drug resistance (MFS-MDR) |
| 6319529 | Splicing factor, component of the U4/U6-U5 snRNP complex |
| 37362616 | Ubiquitin-specific protease that specifically disassembles unanchored ubiquitin chains; involved in fructose-1,6-bisphosphatase (Fbp1p) degradation; similar to human isopeptidase T |
| 6319534 | Subunit of the origin recognition complex, which directs DNA replication by binding to replication origins and is also involved in transcriptional silencing; may be phosphorylated by Cdc28p |
| 6319543 | Amino acid transport protein for valine, leucine, isoleucine, and tyrosine |
| 37362617 | DNA-dependent ATPase, stimulates strand exchange by modifying the topology of double-stranded DNA; involved in the recombinational repair of double-strand breaks in DNA during mitosis and meiosis; proposed to be involved in crossover interference |
| 6319553 | Subunit of the core complex of translation initiation factor 3(eIF3), essential for translation; part of a subcomplex (Prt1p-Rpg1p-Nip1p) that stimulates binding of mRNA and tRNA(i)Met to ribosomes |
| 6319554 | ATPase required for the release of Sec17p during the 'priming' step in homotypic vacuole fusion and for ER to Golgi transport; homolog of the mammalian NSF |
| 6319562 | Subunit of heteropentameric Replication factor C (RF-C), which is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor for DNA polymerases delta and epsilon |
| 6319573 | Myristoylated Serine/threonine protein kinase involved in vacuolar protein sorting |
| 6319590 | Protein that recognizes and binds damaged DNA in an ATP-dependent manner (with Rad7p) during nucleotide excision repair; subunit of Nucleotide Excision Repair Factor 4 (NEF4); member of the SWI/SNF family |
| 6319591 | Alpha aminoadipate reductase, catalyzes the reduction of alpha-aminoadipate to alpha-aminoadipate 6-semialdehyde, which is the fifth step in biosynthesis of lysine; activation requires posttranslational phosphopantetheinylation by Lys5p |
| 6319601 | Cytoplasmic type 2C protein phosphatase; identified as a high-copy number suppressor of the synthetic lethality of a cnb1 mpk1 double deletion; overexpression decreases high-osmolarity induced Hog1p phosphorylation and kinase activity |
| 6319603 | Vacuolar H+ ATPase regulatory subunit (subunit B) of the catalytic (V1) sector |
| 6319608 | Plasma membrane carnitine transporter, expression is down-regulated by osmotic stress; also functions as a low-affinity amino acid permease |
| 6319615 | Hypothetical ORF |
| 6319618 | Essential nucleolar protein, putative DEAD-box RNA helicase required for maintenance of M1 dsRNA virus; involved in biogenesis of large (60S) ribosomal subunits |
| 6319621 | Alcohol dehydrogenase isoenzyme V; involved in ethanol production |
| 6319646 | HSP70 family member, highly homologous to Sse1p |
| 6319647 | Endoplasmic reticulum and nuclear membrane protein, forms a complex with Cdc48p and Ufd1p that recognizes ubiquitinated proteins in the endoplasmic reticulum and delivers them to the proteasome for degradation |
| 6319655 | Possible serine hydrolase, may be involved in lipid metabolism, null mutant slightly temperature sensitive at 37C |
| 6319657 | Multidrug resistance dityrosine transporter of the major facilitator superfamily, essential for spore wall synthesis, facilitates the translocation of bisformyl dityrosine through the prospore membrane |
| 6319672 | Subunit of chromatin assembly factor I (CAF-I), regulates the RAS/cAMP pathway via sequestration of Npr1p kinase; localizes to the nucleus and cytoplasm; homologous to human retinoblastoma binding proteins RbAp48 and RbAp46 |
| 6319675 | Subunit (90 kDa) of TFIID and SAGA complexes, involved in RNA polymerase II transcription initiation and in chromatin modification |
| 6319679 | Component of the hexameric MCM complex, which is important for priming origins of DNA replication in G1 and becomes an active ATP-dependent helicase that promotes DNA melting and elongation when activated by Cdc7p-Dbf4p in S-phase |
| 6319682 | Putative alpha-1,2-mannosyltransferase involved in O- and N-linked protein glycosylation; member of the KRE2/MNT1 mannosyltransferase family |
| 6319699 | Peroxisomal AMP-binding protein, localizes to both the peroxisomal peripheral membrane and matrix, expression is highly inducible by oleic acid, similar to E. coli long chain acyl-CoA synthetase |
| 6319706 | Glucosidase II catalytic subunit required for normal cell wall synthesis; mutations in rot2 suppress tor2 mutations, and are synthetically lethal with rot1 mutations |
| 6319709 | RNA binding protein with similarity to mammalian heterogeneous nuclear RNP K protein, involved in the regulation of telomere position effect and telomere length |
| 6319711 | Essential subunit of the ARP2/3 complex, which is required for the motility and integrity of cortical actin patches |
| 6319712 | Hypothetical ORF |
| 6319713 | Methyltransferase, catalyzes the transfer of a methyl group from S-adenosylmethionine to the GpppN terminus of capped mRNA |
| 6319714 | RNA helicase in the DEAD-box family |
| 6319722 | Member of the imitation-switch (ISWI) class of ATP-dependent chromatin remodeling complexes; ATPase that forms a complex with Ioc2p and Ioc4p to regulate transcription elongation, and a complex with Ioc3p to repress transcription initiation |
| 6319737 | GTPase-activating protein (RhoGAP) for Rho3p and Rho4p, possibly involved in control of actin cytoskeleton organization |
| 37362623 | similar to Rab proteins and other small GTP-binding proteins |
| 6319751 | checkpoint kinase 1; homolog of the S. pombe and mammalian Chk1 checkpoint kinases; Protein kinase Chk1 |
| 6319761 | Hypothetical ORF |
| 6319770 | Permease of basic amino acids in the vacuolar membrane |
| 6319771 | High affinity sulfate permease; sulfate uptake is mediated by specific sulfate transporters Sul1p and Sul2p, which control the concentration of endogenous activated sulfate intermediates |
| 6319772 | P-type metal-transporting ATPase with a role in copper and iron homeostasis; R970G-substitution in the C-terminal region confers cadmium resistance |
| 6319773 | Na+/Pi cotransporter, active in early growth phase; similar to phosphate transporters of Neurospora crassa; transcription regulated by inorganic phosphate concentrations and Pho4p |
| 6319776 | Maltase (alpha-D-glucosidase), inducible protein involved in maltose catabolism; encoded in the MAL3 complex locus; functional in genomic reference strain S288C |
| 6319257 | putative polyol dehydrogenase |
| 6319258 | NAD-dependent (2R,3R)-2,3-butanediol dehydrogenase, a zinc-containing medium-chain alcohol dehydrogenase, produces 2,3-butanediol from acetoin during fermentation and allows using 2,3-butanediol as a carbon source during aerobic growth |
| 6319260 | Functions in endoplasmic reticulum protein quality control; Calnexin and calreticulin homolog |
| 6319268 | Evolutionarily-conserved tail-anchored outer mitochondrial membrane GTPase which regulates mitochondrial morphology; cells lacking Gem1p contain collapsed, globular, or grape-like mitochondria; not required for pheromone-induced cell death |
| 6319282 | GTPase, required for general translation initiation by promoting Met-tRNAiMet binding to ribosomes and ribosomal subunit joining; homolog of bacterial IF2 |
| 6319290 | One of two type V myosins; required for mother-specific HO expression, for the bud tip localization of ASH1 and IST2 mRNA; facilitates growth and orientation of ER tubules along with She3p |
| 6319293 | Integral membrane Ca(2+)-ATPase, potential aminophospholipid translocase required to form a specific class of secretory vesicles that accumulate upon actin cytoskeleton disruption; mutation affects maturation of the 18S rRNA |
| 6319300 | Protein whose overexpression affects chromosome stability, potential Cdc28p substrate; homolog of Snf2p |
| 6319321 | Subunit of heterotrimeric Replication Factor A (RF-A), which is a highly conserved single-stranded DNA binding protein involved in DNA replication, repair, and recombination |
| 6319323 | TyB Gag-Pol protein; proteolytically processed to make the Gag, RT, PR, and IN proteins that are required for retrotransposition |
| 6319327 | Nonessential protein kinase with unknown cellular role |
| 6319328 | Protein kinase of the Mitotic Exit Network that is localized to the spindle pole bodies at late anaphase; promotes mitotic exit by directly switching on the kinase activity of Dbf2p |
| 6319337 | Outer carnitine acetyltransferase, mitochondrial |
| 6319955 | Protein of unknown function, computational analysis of large-scale protein-protein interaction data suggests a possible role in fructose or mannose metabolism |
| 6319963 | Guanine deaminase, a catabolic enzyme of the guanine salvage pathway producing xanthine and ammonia from guanine; activity is low in exponentially-growing cultures but expression is increased in post-diauxic and stationary-phase cultures |
| 6319976 | Component of the septin ring of the mother-bud neck that is required for cytokinesis; septins recruit proteins to the neck and can act as a barrier to diffusion at the membrane, and they comprise the 10nm filaments seen with EM |
| 6319986 | NAD(+)-dependent glutamate dehydrogenase, degrades glutamate to ammonia and alpha-ketoglutarate; expression sensitive to nitrogen catabolite repression and intracellular ammonia levels |
| 6319987 | Protein kinase with a possible role in MAP kinase signaling in the pheromone response pathway |
| 6320001 | DNA repair methyltransferase (6-O-methylguanine-DNA methylase) involved in protection against DNA alkylation damage |
| 6320006 | Essential phosphoprotein component (p150) of the COPII coat of secretory pathway vesicles, in complex with Sec13p; required for ER-derived transport vesicle formation |
| 6320011 | Ubiquitin chain assembly factor (E4) that cooperates with a ubiquitin-activating enzyme (E1), a ubiquitin-conjugating enzyme (E2), and a ubiquitin protein ligase (E3) to conjugate ubiquitin to substrates; also functions as an E3 |
| 6320019 | Homocitrate synthase isozyme, catalyzes the condensation of acetyl-CoA and alpha-ketoglutarate to form homocitrate, which is the first step in the lysine biosynthesis pathway; highly similar to the other isozyme, Lys21p |
| 6320023 | D-lactate dehydrogenase, located in the mitochondrial matrix |
| 6320027 | D-lactate dehydrogenase, oxidizes D-lactate to pyruvate, transcription is heme-dependent, repressed by glucose, and derepressed in ethanol or lactate; located in the mitochondrial inner membrane |
| 6320038 | DNA ligase found in the nucleus and mitochondria, an essential enzyme that joins Okazaki fragments during DNA replication; also acts in nucleotide excision repair, base excision repair, and recombination |
| 6320041 | Cytoplasmic DExD/H-box helicase, stimulates mRNA decapping, coordinates distinct steps in mRNA function and decay, interacts with both the decapping and deadenylase complexes, may have a role in mRNA export and translation |
| 6320042 | Signal transducing MAP kinase kinase involved in pheromone response, where it phosphorylates Fus3p, and in the pseudohyphal/invasive growth pathway, through phosphorylation of Kss1p; phosphorylated by Ste11p, degraded by ubiquitin pathway |
| 6320046 | Involved in mitotic induction and perhaps in DNA replication and spindle assembly; G(sub)2-specific B-type cyclin |
| 6320047 | Protein of the MutS family, forms a dimer with Msh4p that facilitates crossovers between homologs during meiosis; msh5-Y823H mutation confers tolerance to DNA alkylating agents; homologs present in C. elegans and humans |
| 6320052 | Transmembrane protein involved in formation of Cvt and autophagic vesicles; cycles between the pre-autophagosomal structure and other cytosolic punctate structures, not found in autophagosomes |
| 6320056 | Alpha subunit of COPI vesicle coatomer complex, which surrounds transport vesicles in the early secretory pathway |
| 6320060 | Biotin |
| 6320061 | RNA polymerase II largest subunit B220, part of central core; phosphorylation of C-terminal heptapeptide repeat domain regulates association with transcription and splicing factors; similar to bacterial beta-prime |
| 6320063 | Plasma membrane glucose receptor, highly similar to Snf3p; both Rgt2p and Snf3p serve as transmembrane glucose sensors generating an intracellular signal that induces expression of glucose transporter (HXT) genes |
| 6320071 | Homocitrate synthase isozyme, catalyzes the condensation of acetyl-CoA and alpha-ketoglutarate to form homocitrate, which is the first step in the lysine biosynthesis pathway; highly similar to the other isozyme, Lys20p |
| 6320077 | ATPase in ER, nuclear membrane and cytosol with homology to mammalian p97; in a complex with Npl4p and Ufd1p participates in retrotranslocation of ubiquitinated proteins from the ER into the cytosol for degradation by the proteasome |
| 6320085 | Hypothetical ORF |
| 6320089 | Hypothetical ORF |
| 6320099 | Protein of unknown function, similar to O-sialoglycoprotein metallopeptidase from P. haemolytica |
| 6320100 | UDP-N-acetylglucosamine pyrophosphorylase, catalyzes the formation of UDP-N-acetylglucosamine (UDP-GlcNAc), which is important in cell wall biosynthesis, protein N-glycosylation, and GPI anchor biosynthesis |
| 6320101 | Catalytic subunit of DNA polymerase delta; required for chromosomal DNA replication during mitosis and meiosis, intragenic recombination, repair of double strand DNA breaks, and DNA replication during nucleotide excision repair (NER) |
| 6320102 | Cell-cycle checkpoint serine-threonine kinase required for DNA damage-induced transcription of certain target genes, phosphorylation of Rad55p and Sml1p, and transient G2/M arrest after DNA damage; also regulates postreplicative DNA repair |
| 6320113 | Beta subunit of the CAAX farnesyltransferase (FTase) that prenylates the a-factor mating pheromone and Ras proteins; required for the membrane localization of Ras proteins and a-factor; homolog of the mammalian FTase beta subunit |
| 6320118 | Mitochondrial external NADH dehydrogenase, catalyzes the oxidation of cytosolic NADH; Nde1p and Nde2p are involved in providing the cytosolic NADH to the mitochondrial respiratory chain |
| 6320123 | Probable decarboxylase, required for expression of enzymes involved in thiamine biosynthesis; may have a role in catabolism of amino acids to long-chain and complex alcohols |
| 6320124 | Glycogen synthase kinase 3 (GSK-3) homolog; one of four GSK-3 homologs in S. cerevisiae that function to activate Msn2p-dependent transcription of stress responsive genes and that function in protein degradation |
| 6320125 | Cytoplasmic malate dehydrogenase, catalyzes interconversion of malate and oxaloacetate; involved in the glyoxylate cycle |
| 6320143 | Protein required for processing of 20S pre-rRNA in the cytoplasm, associates with pre-40S ribosomal particles |
| 6320151 | fatty acyltransferase homologous to E. coli plsC gene; functionally complements plsC mutants; putative 1-acyl-sn-gylcerol-3-phosphate acyl transferase |
| 6320164 | Subunit of the N-terminal acetyltransferase NatA (Nat1p, Ard1p, Nat5p); N-terminally acetylates many proteins, which influences multiple processes such as the cell cycle, heat-shock resistance, mating, sporulation, and telomeric silencing |
| 6320167 | Protein of unconfirmed function, similar to cell surface flocculin Muc1p; ORF exhibits genomic organization compatible with a translational readthrough-dependent mode of expression |
| 6320168 | Hypothetical ORF |
| 6320172 | tRNA-specific 2-thiouridylase, responsible for 2-thiolation of the wobble base of mitochondrial tRNAs; human ortholog is implicated in myoclonus epilepsy associated with ragged red fibers (MERRF) |
| 6320173 | Putative ATP-dependent RNA helicase of the DEAD-box protein family, constituent of 66S pre-ribosomal particles; essential protein involved in ribosome biogenesis |
| 6320174 | Subunit of the SF3a splicing factor complex, required for spliceosome assembly |
| 6320176 | Dual-specificity kinase required for spindle pole body (SPB) duplication and spindle checkpoint function; substrates include SPB proteins Spc42p, Spc110p, and Spc98p, mitotic exit network protein Mob1p, and checkpoint protein Mad1p |
| 6320179 | Protein of unknown function, potentially phosphorylated by Cdc28p |
| 6320181 | NAD-dependent glycerol-3-phosphate dehydrogenase, key enzyme of glycerol synthesis, essential for growth under osmotic stress; expression regulated by high-osmolarity glycerol response pathway; homolog of Gpd2p |
| 6320187 | DDK (Dbf4-dependent kinase) catalytic subunit required for firing origins and replication fork progression in mitosis through phosphorylation of Mcm2-7p complexes and Cdc45p; kinase activity correlates with cyclical DBF4 expression |
| 6320197 | One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; required for normal peptide hydrolysis by the core 20S particle |
| 6320204 | Neutral trehalase, degrades trehalose; required for thermotolerance and may mediate resistance to other cellular stresses; may be phosphorylated by Cdc28p |
| 6320207 | Protein that stimulates strand exchange by stabilizing the binding of Rad51p to single-stranded DNA; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; forms heterodimer with Rad55p |
| 6320214 | ABC transporter |
| 6320221 | Hypothetical ORF |
| 6320223 | Hypothetical ORF |
| 6320226 | seryl-tRNA synthetase |
| 7839150 | TyB Gag-Pol protein; proteolytically processed to make the Gag, RT, PR, and IN proteins that are required for retrotransposition |
| 6320242 | Lysyl-tRNA synthetase; also identified as a negative regulator of general control of amino acid biosynthesis |
| 6320243 | Protein with similarity to P-type ATPase sodium pumps |
| 6320244 | P-type ATPase sodium pump, involved in Na+ efflux to allow salt tolerance; likely not involved in Li+ efflux |
| 6320245 | P-type ATPase sodium pump, involved in Na+ and Li+ efflux to allow salt tolerance |
| 6320251 | Amino acid permease involved in the uptake of cysteine, leucine, isoleucine and valine |
| 6320266 | Mitochondrial protein, member of the ATP-binding cassette (ABC) transporter family; transcriptionally activated by Yrm1p along with genes involved in multidrug resistance |
| 6320279 | Trehalose-6-phosphate phosphatase |
| 37362631 | Protein involved in rRNA processing; involved in pre-rRNA cleavage at site A2; mutation is synthetically lethal with a gar1 mutation |
| 6320296 | Essential iron-sulfur protein required for ribosome biogenesis and translation initiation; facilitates binding of a multifactor complex (MFC) of translation initiation factors to the small ribosomal subunit; predicted ABC family ATPase |
| 6320298 | Non-essential P-type ATPase that is a potential aminophospholipid translocase, localizes to the plasma membrane and late exocytic or early endocytic membranes, likely involved in protein transport; potential Cdc28p substrate |
| 6320302 | Protein required for mismatch repair in mitosis and meiosis, forms a complex with Msh2p to repair both single-base & insertion-deletion mispairs; potentially phosphorylated by Cdc28p |
| 7839152 | TyB Gag-Pol protein; proteolytically processed to make the Gag, RT, PR, and IN proteins that are required for retrotransposition |
| 6320310 | Putative membrane protein, conserved in mammals |
| 6320312 | multispanning membrane protein |
| 6320317 | putative alanine transaminase (glutamyc pyruvic transaminase) |
| 6320327 | Serine/threonine protein kinase involved in regulation of exocytosis; localizes to the cytoplasmic face of the plasma membrane; closely related to Kin2p |
| 6320331 | Spore Wall Formation |
| 6320334 | Fimbrin, actin-bundling protein; cooperates with Scp1p (calponin/transgelin) in the organization and maintenance of the actin cytoskeleton |
| 6320339 | Vacuolar glutathione S-conjugate transporter of the ATP-binding cassette family, has a role in detoxifying metals such as cadmium, mercury, and arsenite; also transports unconjugated bilirubin; similar to human cystic fibrosis protein CFTR |
| 6320352 | Dihydrolipoyl transsuccinylase, a component of the mitochondrial alpha-ketoglutarate dehydrogenase complex, which catalyzes a step in the tricarboxylic acid (TCA) cycle, the oxidative decarboxylation of alpha-ketoglutarate to succinyl-CoA |
| 6320368 | Sm-like protein involved in docking and fusion of exocytic vesicles through binding to assembled SNARE complexes at the membrane; localization to sites of secretion (bud neck and bud tip) is dependent on SNARE function |
| 6320374 | Guanine nucleotide exchange factor (GEF) for ADP ribosylation factors involved in proliferation of the Golgi, intra-Golgi transport and ER-to-Golgi transport; found in the cytoplasm and on Golgi-associated coated vesicles |
| 6320377 | Translation termination factor eRF3; altered protein conformation creates the [PSI(+)] prion, a dominant cytoplasmically inherited protein aggregate that alters translational fidelity and creates a nonsense suppressor phenotype |
| 6320393 | Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, essential protein that is required for the assembly of actin and tubulins in vivo; contains an ATP-binding motif |
| 6320395 | Hydrophilic protein involved in vesicle trafficking between the ER and Golgi; SM (Sec1/Munc-18) family protein that binds the tSNARE Sed5p and stimulates its assembly into a trans-SNARE membrane-protein complex |
| 6320400 | DEAD-box protein required for efficient splicing of mitochondrial Group I and II introns; presumed RNA helicase due to DEAD-box motif |
| 6320414 | Phosphatidylinositol-4-phosphate 5-kinase, involved in actin cytoskeleton organization and cell morphogenesis; multicopy suppressor of stt4 mutation |
| 7839154 | TyB Gag-Pol protein; proteolytically processed to make the Gag, RT, PR, and IN proteins that are required for retrotransposition |
| 20336767 | TyB Gag-Pol protein; proteolytically processed to make the Gag, RT, PR, and IN proteins that are required for retrotransposition |
| 6320417 | Catalytic epsilon subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a negative regulator of GCN4 expression |
| 6320424 | Septin-related protein expressed during sporulation |
| 6320440 | Homoaconitase, catalyzes the conversion of homocitrate to homoisocitrate, which is a step in the lysine biosynthesis pathway |
| 6320444 | Essential subunit of the COP II vesicle coat, involved in endoplasmic-to-Golgi protein trafficking and maintenance of normal ER morphology; similar to mammalian beta-coat protein (beta-COP) |
| 6320448 | Putative amidase |
| 6320449 | RNA helicase in the DEAD-box family, involved in RNA isomerization at the 5' splice site |
| 6320450 | Peroxisomal membrane signal receptor for C-terminal tripeptide signal sequence (PTS1) of peroxisomal matrix proteins, required for peroxisomal matrix protein import, tetratricopeptide repeat protein, also involved in PTS1-independent import |
| 6320453 | Gene whose overexpression suppresses the synthetic lethality of the hal3 sit4 double mutation |
| 6320462 | Catalase A, breaks down hydrogen peroxide in the peroxisomal matrix formed by acyl-CoA oxidase (Pox1p) during fatty acid beta-oxidation |
| 6320464 | Oligomeric mitochondrial matrix chaperone that cooperates with Ssc1p in mitochondrial thermotolerance after heat shock; prevents the aggregation of misfolded matrix proteins; component of the mitochondrial proteolysis system |
| 7839158 | TyB Gag-Pol protein; proteolytically processed to make the Gag, RT, PR, and IN proteins that are required for retrotransposition |
| 7839160 | TyB Gag-Pol protein; proteolytically processed to make the Gag, RT, PR, and IN proteins that are required for retrotransposition |
| 6320474 | Mitochondrial tryptophanyl-tRNA synthetase |
| 6320475 | copper-transporting P-type ATPase with similarity to human Menkes and Wilsons genes; Cu(2+)-transporting ATPase |
| 6320488 | Hypothetical ORF |
| 6320498 | Signal recognition particle (SRP) receptor - alpha subunit; contain GTPase domains; involved in SRP-dependent protein targeting; interacts with SRP102p |
| 6320500 | Dihydrosphingosine phosphate lyase, regulates intracellular levels of sphingolipid long-chain base phosphates (LCBPs), degrades phosphorylated long chain bases, prefers C16 dihydrosphingosine-l-phosphate as a substrate |
| 6320507 | Functions in cleavage of 3'-ends of pre-mRNAs, prior to polyadenylation; 23.5% identical to the 160-kDa subunit of mammalian cleavage and polyadenylation specificity factor (CPSF-160); Component of pre-mRNA cleavage factor II (CFII); 150-kDa protein associated with polyadenylation factor 1 (PF I) |
| 7839162 | TyB Gag-Pol protein; proteolytically processed to make the Gag, RT, PR, and IN proteins that are required for retrotransposition |
| 6320538 | ER membrane glycoprotein subunit of the glycosylphosphatidylinositol transamidase complex that adds glycosylphosphatidylinositol (GPI) anchors to newly synthesized proteins; human PIG-K protein is a functional homolog |
| 6320539 | Hypothetical ORF |
| 6320541 | Swi2/Snf2-related ATPase, component of the SWR1 complex; required for the incorporation of Htz1p into chromatin |
| 6320548 | Cytoplasmic arginyl-tRNA synthetase |
| 6320561 | anthranilate phosphoribosyl transferase |
| 7839164 | TyB Gag-Pol protein; proteolytically processed to make the Gag, RT, PR, and IN proteins that are required for retrotransposition |
| 6320584 | Oxidoreductase of the mitochondrial inner membrane, involved in cytoplasmic and mitochondrial iron homeostasis and required for activity of Fe-S cluster-containing enzymes; one of the few mitochondrial proteins essential for viability |
| 6320588 | Phenylpyruvate decarboxylase, catalyzes decarboxylation of phenylpyruvate to phenylacetaldehyde, which is the first specific step in the Ehrlich pathway |
| 6320592 | Plasma membrane protein, regulation pattern suggests a possible role in export of ammonia from the cell; member of the TC 9.B.33 YaaH family of putative transporters |
| 6320593 | Elongation factor 2 (EF-2), also encoded by EFT1; catalyzes ribosomal translocation during protein synthesis; contains diphthamide, the unique posttranslationally modified histidine residue specifically ADP-ribosylated by diphtheria toxin |
| 6320595 | Hypothetical ORF |
| 6320598 | Nuclear protein that acts as a heterodimer with Aos1p to activate Smt3p (SUMO) before its conjugation to proteins (sumoylation), which may play a role in protein targeting; essential for viability |
| 6320603 | Nuclear protein; has similarity to Cse1p homologs including Nmd5p, Cse1p, Lph2p, and the human cellular apoptosis susceptibility protein, CAS1; also has similarity to the karyopherin Kap95p |
| 37362635 | uridine nucleosidase (uridine ribohydrolase); EC 3.2.2.3 |
| 6320614 | ATP binding cassette (ABC) transporter of the plasma membrane; general stress response factor implicated in cellular detoxification; target of Pdr1p, Pdr3p and Pdr8p transcription regulators; promoter contains a PDR responsive element |
| 6320624 | SYnthetic lethal with cdcForty; (putative) involved in cell cyle; similar to Drosophila crooked neck |
| 6320639 | Cytosolic metalloprotease; computational analysis of large-scale protein-protein interaction data suggests a possible role in pyruvate metabolism |
| 6320663 | Endosomal Na+/H+ exchanger, required for intracellular sequestration of Na+; required for osmotolerance to acute hypertonic shock |
| 6320668 | Subunit of TFIIH and nucleotide excision repair factor 3 complexes, involved in transcription initiation, required for nucleotide excision repair; ring finger protein similar to mammalian CAK and TFIIH subunit |
| 6320674 | Protein kinase with similarity to mammalian phosphoinositide-dependent kinase 1 (PDK1) and yeast Pkh1p and Pkh2p, two redundant upstream activators of Pkc1p; identified as a multicopy suppressor of a pkh1 pkh2 double mutant |
| 6320685 | AMP-activated serine/threonine protein kinase found in a complex containing Snf4p and members of the Sip1p/Sip2p/Gal83p family; required for transcription of glucose-repressed genes, thermotolerance, sporulation, and peroxisome biogenesis |
| 6320689 | Repressible alkaline phosphatase, a glycoprotein localized to the vacuole; regulated by levels of inorganic phosphate and by a system consisting of Pho4p, Pho9p, Pho80p, Pho81p and Pho85p; dephosphorylates phosphotyrosyl peptides |
| 6320698 | Serine/threonine protein kinase involved in sphingolipid-mediated signaling pathway that controls endocytosis; activates Ypk1p and Ykr2p, components of signaling cascade required for maintenance of cell wall integrity; redundant with Pkh2p |
| 6320704 | Pumilio-homology domain protein that binds ASH1 mRNA at PUF consensus sequences in the 3' UTR and represses its translation, resulting in proper asymmetric localization of ASH1 mRNA |
| 6320705 | Myo-inositol transporter with strong similarity to the minor myo-inositol transporter Itr2p, member of the sugar transporter superfamily; expression is repressed by inositol and choline via Opi1p and derepressed via Ino2p and Ino4p |
| 6320714 | Hypothetical ORF |
| 6320715 | Protein kinase involved in bud growth and assembly of the septin ring, proposed to have kinase-dependent and kinase-independent activities; undergoes autophosphorylation; similar to Kcc4p and Hsl1p |
| 6320717 | High-affinity glutamine permease, also transports Leu, Ser, Thr, Cys, Met and Asn; expression is fully dependent on Grr1p and modulated by the Ssy1p-Ptr3p-Ssy5p (SPS) sensor of extracellular amino acids |
| 6320726 | Protein disulfide isomerase of the endoplasmic reticulum lumen, function overlaps with that of Pdi1p; may interact with nascent polypeptides in the ER |
| 6320731 | Putative protein serine/threonine kinase expressed at the end of meiosis and localized to the prospore membrane, required for correct localization of enzymes involved in spore wall synthesis |
| 6320745 | Glycerol proton symporter of the plasma membrane, subject to glucose-induced inactivation, strongly but transiently induced when cells are subjected to osmotic shock |
| 6320748 | Hypothetical ORF |
| 6322021 | Hypothetical ORF |
| 6322022 | Hypothetical ORF |
| 6322025 | Hypothetical ORF, member of the Dal5p subfamily of the major facilitator family |
| 6322029 | Suc2p |
| 6322036 | Mitochondrial glycerol-3-phosphate dehydrogenase; expression is repressed by both glucose and cAMP and derepressed by non-fermentable carbon sources in a Snf1p, Rsf1p, Hap2/3/4/5 complex dependent manner |
| 6322044 | Histidine kinase osmosensor that regulates a MAP kinase cascade; transmembrane protein with an intracellular kinase domain that signals to Ypd1p and Ssk1p, thereby forming a phosphorelay system similar to bacterial two-component regulators |
| 37362661 | Pantothenate synthase, also known as pantoate-beta-alanine ligase, required for pantothenic acid biosynthesis, deletion causes pantothenic acid auxotrophy, homologous to E. coli panC |
| 6322048 | DNA helicase homolog; homolog of human XPBC, ERCC3 |
| 6322049 | Subunit beta of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo |
| 6322054 | Hypothetical ORF |
| 6322065 | helicase related protein, snf2 homolog |
| 6322067 | NADPH-dependent 1-acyl dihydroxyacetone phosphate reductase found in lipid particles and ER; involved in phosphatidic acid biosynthesis and required for spore germination; capable of metabolizing mammalian steroid hormones |
| 6322075 | Histidinol-phosphate aminotransferase, catalyzes the seventh step in histidine biosynthesis; responsive to general control of amino acid biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts |
| 6322082 | Component of the Sec23p-Sec24p heterodimeric complex of the COPII vesicle coat; involved in ER to Golgi transport, cargo selection and autophagy; required for the binding of the Sec13 complex to ER membranes; homologous to Lst1p and Lss1p |
| 6322083 | Hypothetical ORF |
| 6322092 | Intracellular sporulation-specific glucoamylase involved in glycogen degradation; induced during starvation of a/a diploids late in sporulation, but dispensable for sporulation |
| 6322096 | Protein serine/threonine kinase; regulates the organization and function of the actin cytoskeleton through the phosphorylation of the Pan1p-Sla1p-End3p protein complex |
| 6322097 | Homo-isocitrate dehydrogenase, an NAD-linked mitochondrial enzyme required for the fourth step in the biosynthesis of lysine, in which homo-isocitrate is oxidatively decarboxylated to alpha-ketoadipate |
| 6322100 | Protein required for cell viability |
| 6322106 | Putative mannosyltransferase involved in protein glycosylation; member of the KRE2/MNT1 mannosyltransferase family |
| 6322110 | Hypothetical ORF |
| 14318437 | Threonyl-tRNA synthetase, cytoplasmic |
| 6322123 | Ribonucleotide-diphosphate reductase (RNR), large subunit; the RNR complex catalyzes the rate-limiting step in dNTP synthesis and is regulated by DNA replication and DNA damage checkpoint pathways via localization of the small subunits |
| 6322141 | Protein involved in the retrograde transport from the Golgi complex to the ER and the endosomal membrane traffic; putative aminophospholipid translocase; member of the highly conserved Drs2 family of P-type ATPases |
| 6322146 | cytochrome b reductase |
| 6322147 | Hypothetical ORF |
| 6322151 | Subunit of the CCR4-NOT complex, which is a global transcriptional regulator with roles in transcription initiation and elongation and in mRNA degradation |
| 6322156 | Regulatory subunit of the cyclic AMP-dependent protein kinase (PKA), a component of a signaling pathway that controls a variety of cellular processes, including metabolism, cell cycle, stress response, stationary phase, and sporulation |
| 6322171 | Protein component of the large (60S) ribosomal subunit, identical to Rpl2Ap and has similarity to E. coli L2 and rat L8 ribosomal proteins; expression is upregulated at low temperatures |
| 6322177 | Membrane protein of the ATP-binding cassette (ABC) transporter superfamily, involved in multiple drug resistance, mediates sterol uptake when sterol biosynthesis is compromised, regulated by Pdr1p, required for anaerobic growth |
| 6322179 | Cell wall mannoprotein of the Srp1p/Tip1p family of serine-alanine-rich proteins; expressed under anaerobic conditions and required for anaerobic growth |
| 6322182 | Long chain fatty acyl-CoA synthetase, has a preference for C16 and C18 fatty acids; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery |
| 6322190 | Hypothetical ORF |
| 6322192 | Member of the DEAH family of helicases, functions in an error-free DNA damage bypass pathway that involves homologous recombination, mutations confer a mutator phenotype |
| 6322194 | Cytosolic J-domain-containing protein, required for peroxisomal protein import and involved in peroxisome assembly, homologous to E. coli DnaJ |
| 6322198 | Subunit of DNA primase, which is required for DNA synthesis and double-strand break repair |
| 6322209 | GPI-anchored cell surface glycoprotein required for diploid pseudohyphal formation and haploid invasive growth, transcriptionally regulated by the MAPK pathway (via Ste12p and Tec1p) and the cAMP pathway (via Flo8p) |
| 6322218 | Allantoinase, converts allantoin to allantoate in the first step of allantoin degradation; expression sensitive to nitrogen catabolite repression |
| 6322219 | Allantoin permease; expression sensitive to nitrogen catabolite repression and induced by allophanate, an intermediate in allantoin degradation |
| 6322222 | Malate synthase, role in allantoin degradation unknown; expression sensitive to nitrogen catabolite repression and induced by allophanate, an intermediate in allantoin degradation |
| 6321740 | Transporter, member of the ARN family of transporters that specifically recognize siderophore-iron chelates; responsible for uptake of iron bound to the siderophore triacetylfusarinine C |
| 6321747 | Transporter, member of the ARN family of transporters that specifically recognize siderophore-iron chelates; responsible for uptake of iron bound to ferrirubin, ferrirhodin, and related siderophores |
| 6321752 | Protein of unknown function, member of the ATP-binding cassette (ABC) family, potential Cdc28p substrate |
| 6321756 | v-SNARE protein involved in Golgi transport, homolog of the mammalian protein GOS-28/GS28 |
| 6321759 | cell wall integrity and stress response component 4; Putative integral membrane protein containing novel cysteine motif. Similarity to SLG1 (WSC1), WSC2 and WSC3 |
| 6321760 | Transcriptional repressor involved in the response to pH; required for alkaline pH-stimulated differentiation pathways such as haploid invasive growth and sporulation; activated by proteolytic processing; has similarity to the A. nidulans transcription factor PacC |
| 6321773 | Protein with weak similarity to B. subtilis GTP-binding protein and to human glycogen phosphorylases |
| 6321775 | Hypothetical ORF |
| 6321777 | Hypothetical ORF |
| 7839180 | TyB Gag-Pol protein; proteolytically processed to make the Gag, RT, PR, and IN proteins that are required for retrotransposition |
| 6321780 | Signal transducing kinase of the PAK (p21-activated kinase) family, involved in pheromone response and pseudohyphal/invasive growth pathways, activated by Cdc42p; binds Ste4p at a GBB motif present in noncatalytic domains of PAK kinases |
| 6321784 | Ceramide synthase component, involved in synthesis of ceramide from C26(acyl)-coenzyme A and dihydrosphingosine or phytosphingosine, functionally equivalent to Lac1p |
| 6321799 | Probable mitochondrial seryl-tRNA synthetase, mutant displays increased invasive and pseudohyphal growth |
| 6321803 | Putative RNA-binding protein, interacts with Mex67p, which is a component of the nuclear pore involved in nuclear mRNA export |
| 6321807 | Cytosolic asparaginyl-tRNA synthetase, required for protein synthesis, catalyzes the specific attachment of asparagine to its cognate tRNA |
| 6321808 | Protein required for cell viability |
| 6321812 | Type II myosin heavy chain, required for wild-type cytokinesis and cell separation; localizes to the actomyosin ring; binds to myosin light chains Mlc1p and Mlc2p through its IQ1 and IQ2 motifs respectively |
| 6321816 | Non-ATPase base subunit of the 19S regulatory particle of the 26S proteasome; may participate in the recognition of several ligands of the proteasome; contains a leucine-rich repeat (LRR) domain, a site for protein?protein interactions |
| 6321817 | Dipeptidyl aminopeptidase, synthesized as a glycosylated precursor; localizes to the vacuolar membrane; similar to Ste13p |
| 6321819 | Suppressor of lyt2; serine/threonine MAP kinase |
| 6321820 | DNA helicase involved in rDNA replication and Ty1 transposition; structurally and functionally related to Pif1p |
| 6321822 | Hypothetical ORF |
| 6321824 | Hypothetical ORF |
| 6321826 | Delta-1-pyrroline-5-carboxylate dehydrogenase, nuclear-encoded mitochondrial protein involved in utilization of proline as sole nitrogen source; deficiency of the human homolog causes HPII, an autosomal recessive inborn error of metabolism |
| 6321828 | Protein of unknown function, green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; msc7 mutants are defective in directing meiotic recombination events to homologous chromatids |
| 6321832 | NADP-cytochrome P450 reductase; involved in ergosterol biosynthesis; associated and coordinately regulated with Erg11p |
| 6321837 | Arginine/alanine aminopeptidase, overproduction stimulates glycogen accumulation |
| 6321838 | Hypothetical ORF |
| 6321841 | Divalent metal ion transporter |
| 37362658 | DnaK homolog, interacts with Zuo1p (DnaJ homolog) to form a ribosome-associated complex (RAC) that is bound to the ribosome via the Zuo1p subunit; Hsp70 Protein |
| 6321861 | tRNA(m(1)G37)methyltransferase, methylates a tRNA base adjacent to the anticodon that has a role in prevention of frameshifting; highly conserved across Archaea, Bacteria, and Eukarya |
| 6321863 | Lanosterol synthase, an essential enzyme that catalyzes the cyclization of squalene 2,3-epoxide, a step in ergosterol biosynthesis |
| 6321864 | Member of an oxysterol-binding protein family with seven members in S. cerevisiae; family members have overlapping, redundant functions in sterol metabolism and collectively perform a function essential for viability |
| 6321866 | Protein with carboxyl methyl esterase activity that may have a role in demethylation of the phosphoprotein phosphatase catalytic subunit; also identified as a small subunit mitochondrial ribosomal protein |
| 6321870 | Serine-threonine kinase and endoribonuclease; transmembrane protein that initiates the unfolded protein response signal by regulating synthesis of Hac1p through HAC1 mRNA splicing |
| 6321876 | Transcription factor that is activated by a MAP kinase signaling cascade, activates genes involved in mating or pseudohyphal/invasive growth pathways; cooperates with Tec1p transcription factor to regulate genes specific for invasive growth |
| 6321882 | Yeast homolog of mammalian Ing1; NuA4 histone acetyltransferase complex component |
| 6321883 | Mitochondrial arginyl-tRNA synthetase |
| 6321884 | High-affinity glucose transporter of the major facilitator superfamily, expression is induced by low levels of glucose and repressed by high levels of glucose |
| 6321888 | Hexose transporter with moderate affinity for glucose, may function in accumulation of reserve carbohydrates during stress, expression induced by a decrease in growth rate, contains an extended N-terminal domain relative to other HXTs |
| 6321890 | Member of the Sec24p family; forms a complex, with Sec23p, that is involved in sorting of Pma1p into COPII vesicles; peripheral ER membrane protein; potential Cdc28p substrate |
| 6321891 | Histone acetyltransferase component, putative ortholog of human TRRAP which is an essential cofactor of c-Myc |
| 6321894 | Protein kinase of the PAK/Ste20 kinase family, required for cell integrity possibly through regulating 1,6-beta-glucan levels in the wall; physically interacts with Cdc31p (centrin), which is a component of the spindle pole body |
| 6321899 | Component of the septin ring of the mother-bud neck that is required for cytokinesis; septins recruit proteins to the neck and can act as a barrier to diffusion at the membrane, and they comprise the 10nm filaments seen with EM |
| 6321903 | Protein that activates Urm1p before its conjugation to proteins (urmylation); one target is the thioredoxin peroxidase Ahp1p, suggesting a role of urmylation in the oxidative stress response |
| 6321904 | Hypothetical ORF |
| 6321912 | DNA-binding protein of the mitochondria involved in repair of mitochondrial DNA, has ATPase activity and binds to DNA mismatches; has homology to E. coli MutS; transcription is induced during meiosis |
| 6321915 | sn-1,2-diacylglycerol ethanolamine- and cholinephosphotranferase; not essential for viability |
| 37362660 | Uracil phosphoribosyltransferase, synthesizes UMP from uracil; involved in the pyrimidine salvage pathway |
| 6321924 | Non-essential protein of unknown function, similar to zinc carboxypeptidase family |
| 6321929 | Aromatic aminotransferase, catalyzes the first step of tryptophan, phenylalanine, and tyrosine catabolism |
| 6321960 | Subunit of the anaphase-promoting complex/cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition |
| 6321962 | Putative GTPase, member of the Obg family; peripheral protein of the mitochondrial inner membrane that associates with the large ribosomal subunit; required for mitochondrial translation, possibly via a role in ribosome assembly |
| 6321965 | Autophagy-related protein that is a member of the E1 family of ubiquitin-activating enzymes; mediates the conjugation of Atg12p with Atg5p, a required step in the formation of autophagosomes |
| 41629686 | Flavin-containing monooxygenase, localized to the cytoplasmic face of the ER membrane; catalyzes oxidation of biological thiols to maintain the ER redox buffer ratio for correct folding of disulfide-bonded proteins |
| 6321973 | Widely conserved NADPH oxidoreductase containing flavin mononucleotide (FMN), homologous to Oye3p with slight differences in ligand binding and catalytic properties; may be involved in sterol metabolism |
| 6321980 | Subunit of TORC1, a rapamycin-sensitive complex involved in growth control that contains Tor1p or Tor2p, Lst8p and Tco89p; contains four HEAT repeats and seven WD-40 repeats; may act as a scaffold protein to couple TOR and its effectors |
| 6321984 | Farnesyl-diphosphate farnesyl transferase (squalene synthase), joins two farnesyl pyrophosphate moieties to form squalene in the sterol biosynthesis pathway |
| 6321999 | Protein kinase that regulates signal transduction activity and G1 progression, controls cAPK activity, required for nitrogen activation of the FGM pathway, involved in life span regulation, homologous to mammalian Akt/PKB |
| 6322000 | Protein with similarity to DNA-binding region of heat shock transcription factors; transcription factor involved in oxidative stress response |
| 6322012 | Inosine monophosphate dehydrogenase, catalyzes the first step of GMP biosynthesis, expression is induced by mycophenolic acid resulting in resistance to the drug, expression is repressed by nutrient limitation |
| 6321181 | Alcohol dehydrogenase type IV, dimeric enzyme demonstrated to be zinc-dependent despite sequence similarity to iron-activated alcohol dehydrogenases; transcription is induced in response to zinc deficiency; alcohol dehydrogenase isoenzyme IV |
| 37362649 | Glutamyl-tRNA synthetase (GluRS), forms a complex with methionyl-tRNA synthetase (Mes1p) and Arc1p; complex formation increases the catalytic efficiency of both tRNA synthetases and ensures their correct localization to the cytoplasm |
| 6321198 | Nuclear envelope protein that mediates the nuclear export of importin alpha (Srp1p), homolog of metazoan CAS protein, required for accurate chromosome segregation |
| 50593214 | Mitochondrial protein, forms a heterodimer complex with Mss1p that performs the 5-carboxymethylaminomethyl modification of the wobble uridine base in mitochondrial tRNAs; required for respiration in paromomycin-resistant 15S rRNA mutants |
| 6321221 | Kinesin-related motor protein involved in mitotic spindle positioning |
| 6321231 | Subunit of the heterodimeric FACT complex (Spt16p-Pob3p), facilitates RNA Polymerase II transcription elongation through nucleosomes by destabilizing and then reassembling nucleosome structure |
| 6321233 | Fatty-acyl coenzyme A oxidase, involved in the fatty acid beta-oxidation pathway; localized to the peroxisomal matrix |
| 6321236 | Aromatic aminotransferase, expression is regulated by general control of amino acid biosynthesis |
| 41629691 | Protein involved in DNA replication; component of the Mcm2-7 hexameric complex that binds chromatin as a part of the pre-replicative complex |
| 6321238 | Integral membrane component of endoplasmic reticulum-derived COPII-coated vesicles, which function in ER to Golgi transport |
| 6321253 | Putative hydroxyacid dehydrogenase |
| 6321258 | Protein serine/threonine kinase, required for autophagy and for the cytoplasm-to-vacuole targeting (Cvt) pathway |
| 6321259 | Putative protein kinase, related to and redundant with Elm1p and Pak1p in activating the SNF1 complex |
| 6321265 | 5'-3' exonuclease involved in mRNA decay, evolutionarily conserved component of cytoplasmic processing (P) bodies, plays a role in microtubule-mediated processes, filamentous growth, and ribosomal RNA maturation |
| 6321267 | ATP-dependent RNA helicase of the DEAD box family; required for 18S rRNA synthesis |
| 6321269 | Protein required for respiratory growth; null mutation suppresses the Cyc1p translation defect caused by the presence of an aberrant ATG codon upstream of the correct start |
| 6321271 | High affinity Ca2+/Mn2+ P-type ATPase required for Ca2+ and Mn2+ transport into Golgi; involved in Ca2+ dependent protein sorting and processing; mutations in human homolog ATP2C1 cause acantholytic skin condition Hailey-Hailey disease |
| 6321275 | DNA-dependent ATPase, stimulates strand exchange by modifying the topology of double-stranded DNA; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; member of the SWI/SNF family |
| 6321280 | Protein kinase involved in the response to oxidative stress; identified as suppressor of S. pombe cell cycle checkpoint mutations |
| 6321282 | vacuolar alpha mannosidase |
| 6321289 | ATPase that forms a large complex, containing actin and several actin-related proteins, that has chromatin remodeling activity and 3' to 5' DNA helicase activity in vitro; shows similarity to the Snf2p family of ATPases |
| 6321295 | Mitochondrial polypeptide chain release factor, involved in stop codon recognition and hydrolysis of the peptidyl-tRNA bond during mitochondrial translation; lack of MRF1 causes mitochondrial genome instability |
| 6321296 | Integral membrane protein involved in glycosylphosphatidylinositol (GPI) anchor synthesis; putative alpha 1,2 mannosyltransferase required for addition of the third mannose onto the GPI core structure; human PIG-Bp is a functional homolog |
| 6321297 | Protein with similarity to hect domain E3 ubiquitin-protein ligases, not essential for viability |
| 6321301 | Essential subunit of the COP II vesicle coat, involved in ER-to-Golgi protein trafficking and in retrograde Golgi-to-ER transport; contains WD40 domains that mediate cargo selective interactions; similar to mammalian beta'-coat protein |
| 6321319 | Protein required for ubiquinone (coenzyme Q) biosynthesis, which in turn is required for respiratory growth; has similarity to prokaryotic proteins involved in early steps of ubiquinone biosynthesis |
| 6321322 | Cell-cycle regulated activator of anaphase-promoting complex/cyclosome (APC/C), which is required for metaphase/anaphase transition; directs ubiquitination of mitotic cyclins, Pds1p, and other anaphase inhibitors; potential Cdc28p substrate |
| 6321324 | Putative member of the oligopeptide transporter (OPT) family of membrane transporters |
| 6321326 | Subunit (60 kDa) of TFIID and SAGA complexes, involved in transcription initiation of RNA polymerase II and in chromatin modification, similar to histone H4 |
| 6321333 | Protein that binds tRNA and methionyl- and glutamyl-tRNA synthetases (Mes1p and Gus1p), delivering tRNA to them, stimulating catalysis, and ensuring their localization to the cytoplasm; also binds quadruplex nucleic acids |
| 6321334 | Vps73p |
| 6321339 | Putative GTPase involved in 60S ribosomal subunit biogenesis; localized to the cytoplasm |
| 6321341 | Nucleotide exchange factor for Gsp1p, localizes to the nucleus, required for nucleocytoplasmic trafficking of macromolecules; potentially phosphorylated by Cdc28p |
| 6321360 | Putative ATP-dependent RNA helicase of the DEAD-box family involved in ribosomal biogenesis |
| 6321361 | Choline transporter (permease) that also controls the uptake of nitrogen mustard; expression is co-regulated with phospholipid biosynthetic genes and negatively regulated by choline and myo-inositol |
| 6321371 | NADH diphosphatase (pyrophosphatase), hydrolyzes the pyrophosphate linkage in NADH and related nucleotides; localizes to peroxisomes |
| 6321374 | Mitochondrial RNA helicase, plays an essential role in mitochondrial function |
| 27808706 | Hypothetical ORF |
| 6321383 | Fatty acid desaturase, required for monounsaturated fatty acid synthesis and for normal distribution of mitochondria |
| 6321395 | General transcription elongation factor TFIIS, enables RNA polymerase II to read through blocks to elongation by stimulating cleavage of nascent transcripts stalled at transcription arrest sites |
| 6321403 | Transcription factor involved in glucose repression; C2H2 zinc finger protein similar to mammalian Egr and Wilms tumor proteins |
| 6321410 | Cell wall protein with similarity to glucanases; may play a role in conjugation during mating based on its regulation by Ste12p |
| 6321411 | Processing alpha glucosidase I, involved in assembly of cell wall beta 1,6 glucan and asparagine-linked protein glycosylation; ER type II integral membrane N-glycoprotein; disruption leads to a K1 killer toxin-resistant phenotype |
| 6321424 | Member of the PUF protein family, which is defined by the presence of Pumilio homology domains that confer RNA binding activity; preferentially binds mRNAs encoding nucleolar ribosomal RNA-processing factors |
| 6321426 | C-24(28) sterol reductase, catalyzes the final step in ergosterol biosynthesis; mutants are viable, but lack ergosterol |
| 6321429 | Isopropylmalate isomerase, catalyzes the second step in the leucine biosynthesis pathway |
| 6321430 | Plasma membrane H+-ATPase, pumps protons out of the cell; major regulator of cytoplasmic pH and plasma membrane potential; part of the P2 subgroup of cation-transporting ATPases |
| 6321432 | Vacuolar Ca2+ ATPase involved in depleting cytosol of Ca2+ ions; prevents growth inhibition by activation of calcineurin in the presence of elevated concentrations of calcium |
| 6321435 | CDC20 homolog 1; protein required for Clb2 and Ase1 degradation |
| 6321440 | Ubiquitin-protein ligase, member of the cullin family with similarity to Cdc53p and human CUL3; null mutation has no apparent phenotype |
| 6321451 | Mucin family member at the head of the Cdc42p- and MAP kinase-dependent filamentous growth signaling pathway; also functions as an osmosensor in parallel to the Sho1p-mediated pathway; potential Cdc28p substrate |
| 6321456 | Gamma-aminobutyrate (GABA) transaminase (4-aminobutyrate aminotransferase) involved in the 4-aminobutyrate and glutamate degradation pathways; required for normal oxidative stress tolerance and nitrogen utilization |
| 6321458 | Hypothetical ORF |
| 6321459 | Protein with both structural and functional similarity to Mid2p, which is a plasma membrane sensor required for cell integrity signaling during pheromone-induced morphogenesis; suppresses rgd1 null mutations |
| 7839171 | TyB Gag-Pol protein; proteolytically processed to make the Gag, RT, PR, and IN proteins that are required for retrotransposition |
| 6321465 | Mitochondrial protein involved in sorting of proteins in the mitochondria; putative membrane-spanning ATPase |
| 6321469 | Catalytic subunit of 1,3-beta-glucan synthase, has similarity to an alternate catalytic subunit, Fks1p (Gsc1p); Rho1p encodes the regulatory subunit; involved in cell wall synthesis and maintenance |
| 7839173 | TyB Gag-Pol protein; proteolytically processed to make the Gag, RT, PR, and IN proteins that are required for retrotransposition |
| 6321485 | Protein that interacts with Cdc48p and Npl4p, involved in recognition of polyubiquitinated proteins and their presentation to the 26S proteasome for degradation; involved in transporting proteins from the ER to the cytosol |
| 6321489 | The authentic, non-tagged protein was localized to the mitochondria |
| 6321491 | yeast homolog of mammalian eIF2A |
| 6321492 | High affinity methionine permease, integral membrane protein with 13 putative membrane-spanning regions; also involved in cysteine uptake |
| 6321496 | a sporulation-specific homologue of the yeast CDC3/10/11/12 family of bud neck microfilament genes; regulated by ABFI; septin protein involved in sporulation |
| 6321498 | Formylglycinamidine-ribonucleotide (FGAM)-synthetase, catalyzes a step in the 'de novo' purine nucleotide biosynthetic pathway |
| 6321520 | Delta subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a negative regulator of GCN4 expression |
| 6321525 | Cytosolic catalase T, has a role in protection from oxidative damage by hydrogen peroxide |
| 6321528 | Splicing factor, component of the U4/U6-U5 snRNP complex |
| 6321529 | Ser/Thr kinase involved in transcription and stress response; functions as part of a network of genes in exit from mitosis; localization is cell cycle regulated; activated by Cdc15p during the exit from mitosis |
| 6321531 | mitochondrial and cytoplasmic valyl-tRNA synthetase |
| 6321537 | Cytoplasmic GTPase-activating protein for Ypt/Rab transport GTPases Ypt6p, Ypt31p and Sec4p; involved in recycling of internalized proteins and regulation of Golgi secretory function |
| 6321545 | Involved in mitotic induction; G(sub)2-specific B-type cyclin |
| 6321546 | role in DNA replication during S phase; B-type cyclin |
| 6321547 | TyB Gag-Pol protein; proteolytically processed to make the Gag, RT, PR, and IN proteins that are required for retrotransposition |
| 6321552 | Essential protein that interacts with histones and is involved in nucleosome disassembly and reassembly during transcription elongation |
| 6321562 | Protein serine/threonine phosphatase with similarity to human phosphatase PP5; present in both the nucleus and cytoplasm; expressed during logarithmic growth |
| 6321584 | Essential nucleolar protein of unknown function; contains WD repeats, interacts with Mpp10p and Bfr2p, and has homology to Spb1p |
| 6321591 | GTP-binding protein of the ras superfamily required for bud site selection, morphological changes in response to mating pheromone, and efficient cell fusion; localized to the plasma membrane; significantly similar to mammalian Rap GTPases |
| 6321594 | Cystathionine beta-synthase, catalyzes the synthesis of cystathionine from serine and homocysteine, the first committed step in cysteine biosynthesis |
| 7839178 | TyB Gag-Pol protein; proteolytically processed to make the Gag, RT, PR, and IN proteins that are required for retrotransposition |
| 6321608 | Pseudouridine synthase responsible for modification of cytoplasmic and mitochondrial tRNAs at position 31; mutation of Asp168 to Ala abolishes enzyme activity; not essential for viability |
| 6321610 | Mitochondrial methionyl-tRNA synthetase (MetRS), functions as a monomer in mitochondrial protein synthesis; functions similarly to cytoplasmic MetRS although the cytoplasmic form contains a zinc-binding domain not found in Msm1p |
| 6321629 | High-affinity histidine permease, also involved in the transport of manganese ions |
| 6321632 | Dihydrolipoamide dehydrogenase (E3)-binding protein (E3BP) of the mitochondrial pyruvate dehydrogenase (PDH) complex, plays a structural role in the complex by binding and positioning E3 to the dihydrolipoamide acetyltransferase (E2) core |
| 6321633 | third enzyme in the xylose pathway; Xylulokinase |
| 6321639 | Elongator protein, part of the six-subunit RNA polymerase II Elongator histone acetyltransferase complex; target of Kluyveromyces lactis zymocin |
| 6321641 | Cholinephosphate cytidylyltransferase, also known as CTP |
| 6321647 | phosphoserine phosphatase |
| 6321649 | Hypothetical ORF |
| 6321656 | Voltage-gated calcium channel involved in calcium influx in response to mating pheromones |
| 6321662 | Phosphatidylinositol 3,5-bisphosphate-binding protein, predicted to fold as a seven-bladed beta-propeller; displays punctate cytoplasmic localization |
| 6321663 | Plasma membrane transporter of the major facilitator superfamily, involved in resistance to azole drugs such as ketoconazole and fluconazole |
| 6681847 | Required for sporulation, highly induced during sporulation; activator of meiotic anaphase promoting complex; Required for sporulation; highly induced during sporulation |
| 6321673 | Flavohemoglobin; may play a role in the oxidative stress response |
| 6321685 | TFIIIB B-related factor, one of three subunits of RNA polymerase III transcription initiation factor TFIIIB, binds TFIIIC and TBP and recruits RNA pol III to promoters, amino-terminal half is homologous to TFIIB |
| 6321691 | Histone acetyltransferase, acetylates lysine 14 on histone H3; catalytic subunit of the ADA and SAGA histone acetyltransferase complexes; founding member of the Gcn5p-related N-acetyltransferase superfamily |
| 6321694 | Putative flavin-dependent monooxygenase, involved in ubiquinone (Coenzyme Q) biosynthesis; located on the matrix side of the mitochondrial inner membrane |
| 6321697 | Single-stranded DNA endonuclease, cleaves single-stranded DNA during nucleotide excision repair to excise damaged DNA; subunit of Nucleotide Excision Repair Factor 3 (NEF3); homolog of human XPG protein |
| 6321700 | beta3-like subunit of the yeast AP-3 complex which functions in transport of alkaline phosphatase to the vacuole via the alternate pathway, suppressor of loss of casein kinase 1 function; putative beta adaptin component of the membrane-associate clathrin assembly complex |
| 6321704 | Methionyl-tRNA synthetase, forms a complex with glutamyl-tRNA synthetase (Gus1p) and Arc1p, which increases the catalytic efficiency of both tRNA synthetases; also has a role in nuclear export of tRNAs |
| 6321709 | Protein of unknown function, member of CDC48/PAS1/SEC18 family of ATPases, potentially phosphorylated by Cdc28p |
| 6321713 | TFIID subunit (145 kDa), involved in RNA polymerase II transcription initiation, has histone acetyltransferase activity, involved in promoter binding and G1/S progression |
| 6321715 | 3' exoribonuclease, required for 5S and tRNA-Arg3 maturation |
| 6321720 | Plasma membrane transporter of the ATP-binding cassette (ABC) family, mediates export of many different organic anions including oligomycin |
| 6321726 | Hypothetical ORF |
| 6321731 | Maltase (alpha-D-glucosidase), inducible protein involved in maltose catabolism; encoded in the MAL1 complex locus |
| 14318464 | Low-affinity amino acid permease, may act to supply the cell with amino acids as nitrogen source in nitrogen-poor conditions; transcription is induced under conditions of sulfur limitation |
| 14318466 | Dihydroxyacetone kinase, required for detoxification of dihydroxyacetone (DHA); involved in stress adaptation |
| 14318477 | Multicopper oxidase, integral membrane protein with similarity to Fet3p; may have a role in iron transport |
| 14318478 | Hypothetical ORF |
| 14318482 | Mitochondrial RNA polymerase; single subunit enzyme similar to those of T3 and T7 bacteriophages; requires a specificity subunit encoded by MTF1 for promoter recognition |
| 14318489 | Alanine |
| 14318490 | Cyclin-dependent kinase-activating kinase required for passage through the cell cycle, phosphorylates and activates Cdc28p; nucleotide-binding pocket differs significantly from those of most other protein kinases |
| 14318491 | Part of the evolutionarily-conserved CCR4-NOT transcriptional regulatory complex involved in controlling mRNA initiation, elongation, and degradation; putative ABC ATPase; interacts with Ssn2p, Ssn3p, and Ssn8p |
| 14318497 | Alpha subunit of cytoplasmic phenylalanyl-tRNA synthetase, forms a tetramer with Frs1p to form active enzyme; evolutionarily distant from mitochondrial phenylalanyl-tRNA synthetase based on protein sequence, but substrate binding is similar |
| 14318504 | Protein involved in folding of mitochondrially synthesized proteins in the mitochondrial matrix; localizes to the mitochondrial inner membrane; member of the DnaJ family of molecular chaperones |
| 14318514 | Subunit of the multiprotein cohesin complex, essential protein involved in chromosome segregation and in double-strand DNA break repair; SMC chromosomal ATPase family member, binds DNA with a preference for DNA with secondary structure |
| 14318519 | Protein involved in meiotic recombination, required for normal levels of crossing over, colocalizes with Zip2p to discrete foci on meiotic chromosomes, has homology to bacterial MutS protein |
| 14318520 | TyB Gag-Pol protein; proteolytically processed to make the Gag, RT, PR, and IN proteins that are required for retrotransposition |
| 14318521 | involved in the maturation of 25S ribosomal RNA; ATP-dependent RNA helicase |
| 14318528 | Hypothetical ORF |
| 14318531 | Positive regulator of the Gcn2p kinase activity, forms a complex with Gcn1p; proposed to stimulate Gcn2p activation by an uncharged tRNA |
| 14318536 | Calmodulin-dependent protein kinase |
| 14318540 | Hypothetical ORF |
| 14318545 | Poly(A) binding protein, suppressor of DNA polymerase epsilon mutation, similar to Mip6p |
| 14318551 | Protein phosphatase required for mitotic exit; located in the nucleolus until liberated by the FEAR and Mitotic Exit Network in anaphase, enabling it to act on key substrates to effect a decrease in CDK/B-cyclin activity and mitotic exit |
| 14318553 | Subunit alpha of assimilatory sulfite reductase, which is responsible for the conversion of sulfite into sulfide |
| 14318554 | Component of the condensin complex, essential SMC chromosomal ATPase family member that forms a complex with Smc4p to form the active ATPase; Smc2p/Smc4p complex binds DNA, possibly in the cleft formed by the coiled-coil of the folded dimer |
| 14318555 | Protein component of the large (60S) ribosomal subunit, identical to Rpl2Bp and has similarity to E. coli L2 and rat L8 ribosomal proteins |
| 42742173 | Hypothetical ORF |
| 14318569 | Hypothetical ORF |
| 19705600 | Quinolinate phosphoribosyl transferase, required for biosynthesis of nicotinic acid from tryptophan via kynurenine pathway |
| 14318576 | Delta subunit of the coatomer complex (COPI), which coats Golgi-derived transport vesicles; involved in retrograde transport between Golgi and ER |
| 6320764 | D-lactate dehydrogenase, part of the retrograde regulon which consists of genes whose expression is stimulated by damage to mitochondria and reduced in cells grown with glutamate as the sole nitrogen source, located in the cytoplasm |
| 6320772 | Plasma membrane arginine permease, requires phosphatidyl ethanolamine (PE) for localization, exclusively associated with lipid rafts; mutation confers canavanine resistance |
| 37362641 | Kinesin motor protein involved in mitotic spindle assembly and chromosome segregation |
| 6320775 | Vacuolar proteinase B (yscB), a serine protease of the subtilisin family; involved in protein degradation in the vacuole and required for full protein degradation during sporulation |
| 6320788 | Fumurate ReDuctase Soluble |
| 6320789 | Threonine aldolase, catalyzes the cleavage of L-allo-threonine and L-threonine to glycine; involved in glycine biosynthesis |
| 6320794 | Hypothetical ORF |
| 6320803 | Protein involved in DNA replication; component of the Mcm2-7 hexameric complex that binds chromatin as a part of the pre-replicative complex |
| 6320804 | Sensitivity to a killer toxin (SMK toxin) produced by Pichia Farinosa; P-type ATPase |
| 6320806 | Protein involved in bud-site selection; diploid mutants display a random budding pattern instead of the wild-type bipolar pattern; has similarity to pyridoxal kinases |
| 6320816 | Hypothetical ORF |
| 6320826 | Glycogen branching enzyme, involved in glycogen accumulation; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern |
| 6320835 | wheat germ agglutinin-binding protein; oligosaccharyl transferase glycoprotein complex, beta subunit |
| 6320842 | GTPase that associates with nuclear 60S pre-ribosomes, required for export of 60S ribosomal subunits from the nucleus |
| 6320848 | Cell wall mannoprotein of the Srp1p/Tip1p family of serine-alanine-rich proteins; expression is downregulated at acidic pH and induced by cold shock and anaerobiosis; abundance is increased in cells cultured without shaking |
| 6320850 | RNA-dependent ATPase/ATP-dependent RNA helicase in the DEAH-box family, associates with the lariat intermediate before the second catalytic step of splicing |
| 6320852 | Long chain fatty acyl-CoA synthetase; accepts a wider range of acyl chain lengths than Faa1p, preferring C9 |
| 6320854 | Component, with Yta12p, of the mitochondrial inner membrane m-AAA protease that mediates degradation of misfolded or unassembled proteins and is also required for correct assembly of mitochondrial enzyme complexes |
| 6320856 | Inositol phosphosphingolipid phospholipase C, hydrolyzes inositolphosphosphingolipids, activated by phosphatidylserine, cardiolipin, and phosphatidylglycerol, mediates Na+ and Li+ halotolerance, contains a P loop-like domain |
| 6320858 | Nucleotide binding alpha subunit of the heterotrimeric G protein that interacts with the receptor Gpr1p, has signaling role in response to nutrients; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery |
| 6320859 | Essential, non-ATPase regulatory subunit of the 26S proteasome lid, similar to the p58 subunit of the human 26S proteasome; temperature-sensitive alleles cause metaphase arrest, suggesting a role for the proteasome in cell cycle control |
| 6320861 | Delta 1-pyrroline-5-carboxylate reductase, catalyzes the last step in proline biosynthesis |
| 6320867 | associated with U1, U2, U4, and U5 snRNPs as part of the Sm-core that is common to all spliceosomal snRNPs; U1 snRNP protein |
| 6320874 | ATPase of the ATP-binding cassette (ABC) family involved in ribosome biogenesis, has similarity to Gcn20p |
| 6320887 | Putative ATPase of the AAA family, interacts with the Sin1p transcriptional repressor in the two-hybrid system |
| 6320888 | Nuclear type II J heat shock protein of the E. coli dnaJ family, contains a leucine zipper-like motif, binds to non-native substrates for presentation to Ssa3p, may function during protein translocation, assembly and disassembly |
| 6320893 | Aspartate kinase (L-aspartate 4-P-transferase); cytoplasmic enzyme that catalyzes the first step in the common pathway for methionine and threonine biosynthesis; expression regulated by Gcn4p and the general control of amino acid synthesis |
| 6320904 | homology with beta-keto-acyl synthases; Protein homologous to beta-keto-acyl synthase |
| 6320914 | Ribonucleotide-diphosphate reductase (RNR), large subunit; the RNR complex catalyzes the rate-limiting step in dNTP synthesis and is regulated by DNA replication and DNA damage checkpoint pathways via localization of the small subunits |
| 6320926 | Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA |
| 6320931 | Hypothetical ORF |
| 6320934 | Type 2C protein phosphatase; dephosphorylates Hog1p to limit maximal osmostress induced kinase activity; dephosphorylates Ire1p to downregulate the unfolded protein response; dephosphorylates Cdc28p; role in DNA checkpoint inactivation |
| 6320935 | anthranilate synthase Component I |
| 6320945 | Ubiquitin-specific protease that cleaves ubiquitin-protein fusions |
| 6320947 | Ubiquitin-conjugating enzyme involved in ER-associated protein degradation; located at the cytosolic side of the ER membrane; tail region contains a transmembrane segment at the C-terminus; substrate of the ubiquitin-proteasome pathway |
| 6320959 | Hypothetical ORF |
| 7276233 | plasma membrane-bound casein kinase I homolog |
| 6320972 | Ubiquitin-protein ligase involved in ubiquitin-mediated protein degradation; plays a role in heat shock element (HSE)-mediated gene expression and multivesicular body sorting; contains a hect (homologous to E6-AP carboxyl terminus) domain |
| 6320976 | Upstream kinase for the SNF1 complex; partially redundant function with Elm1p and Tos3p; members of this family of kinases have functional orthology with LKB1, a mammalian kinase associated with Peutz-Jeghers cancer-susceptibility syndrome |
| 6320985 | TyB Gag-Pol protein; proteolytically processed to make the Gag, RT, PR, and IN proteins that are required for retrotransposition |
| 6320989 | Protein required for the hydroxylation of heme O to form heme A, which is an essential prosthetic group for cytochrome c oxidase |
| 6320991 | DNA damage-inducible v-SNARE binding protein, contains a ubiquitin-associated (UBA) domain, may act as a negative regulator of constitutive exocytosis, may play a role in S-phase checkpoint control |
| 6320992 | Putative ubiquitin-specific protease that does not associate with the proteasome |
| 6321000 | Hypothetical ORF |
| 6321002 | Translocase of the mitochondrial inner membrane, mediates the insertion of both mitochondrial- and nuclear-encoded proteins from the matrix into the inner membrane, interacts with mitochondrial ribosomes; null is respiratory deficient |
| 6321008 | TyB Gag-Pol protein; proteolytically processed to make the Gag, RT, PR, and IN proteins that are required for retrotransposition |
| 6321012 | Sole S. cerevisiae member of CHD gene family containing Chromodomain, Helicase domain, and DNA-binding domain; transcriptional regulator |
| 6321014 | Non-essential P-type ATPase that is a potential aminophospholipid translocase, localizes to the plasma membrane and late exocytic or early endocytic membranes, likely involved in protein transport |
| 6321016 | tRNA nucleotidyltransferase (tRNA CCA-pyrophosphorylase) |
| 6321024 | DNA dependent ATPase/DNA helicase belonging to the Dna2p- and Nam7p-like family of helicases that is involved in modulating translation termination; interacts with the translation termination factors, localized to polysomes |
| 37362644 | E1 alpha subunit of the pyruvate dehydrogenase (PDH) complex, catalyzes the direct oxidative decarboxylation of pyruvate to acetyl-CoA, regulated by glucose |
| 6323537 | 123 kD regulatory subunit of trehalose-6-phosphate synthase/phosphatase complex; homologous to TPS3 gene product |
| 6323541 | Protein required for Golgi to vacuole trafficking, has similarity with mammalian ras inhibitors |
| 6323546 | Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA |
| 6323552 | Hypothetical ORF |
| 6323553 | D-Arabinono-1,4-lactone oxidase, catalyzes the final step in biosynthesis of D-erythroascorbic acid, which is protective against oxidative stress |
| 6323565 | One of two isozymes of HMG-CoA reductase that catalyzes the conversion of HMG-CoA to mevalonate, which is a rate-limiting step in sterol biosynthesis; localizes to the nuclear envelope; overproduction induces the formation of karmellae |
| 6323573 | Protein localized to COPII-coated vesicles, forms a complex with Erv46p; involved in the membrane fusion stage of transport |
| 6323575 | Largest subunit of the origin recognition complex, which directs DNA replication by binding to replication origins and is also involved in transcriptional silencing; may be phosphorylated by Cdc28p |
| 6323585 | Inosine monophosphate dehydrogenase, catalyzes the first step of GMP biosynthesis, member of a four-gene family in S. cerevisiae, constitutively expressed |
| 6323592 | RNA splicing and ER to Golgi transport; involved in secretion and RNA splicing |
| 6323597 | TyB Gag-Pol protein; proteolytically processed to make the Gag, RT, PR, and IN proteins that are required for retrotransposition |
| 6323601 | TyB Gag-Pol protein; proteolytically processed to make the Gag, RT, PR, and IN proteins that are required for retrotransposition |
| 6323606 | AMP deaminase, tetrameric enzyme that catalyzes the deamination of AMP to form IMP and ammonia; may be involved in regulation of intracellular adenine nucleotide pools |
| 6323620 | uracil DNA glycosylase |
| 6323630 | Protein that forms a heterotrimeric complex with Erp1, Erp2p, and Emp24, member of the p24 family involved in endoplasmic reticulum to Golgi transport |
| 6323632 | Protein that forms a complex with Spt4p and mediates both activation and inhibition of transcription elongation; Spt4p-Spt5p complex also plays a role in pre-mRNA processing |
| 6323643 | Polo-like kinase with similarity to Xenopus Plx1 and S. pombe Plo1p; found at bud neck, nucleus and SPBs; has multiple functions in mitosis and cytokinesis through phosphorylation of substrates; may be a Cdc28p substrate |
| 6323653 | High-affinity glucose transporter of the major facilitator superfamily, expression is induced by low levels of glucose and repressed by high levels of glucose |
| 6323654 | CLU1 is similar to the Dictyostelium cluA gene; translation initiation factor eIF3 subunit |
| 6323657 | C-22 sterol desaturase, a cytochrome P450 enzyme that catalyzes the formation of the C-22(23) double bond in the sterol side chain in ergosterol biosynthesis; may be a target of azole antifungal drugs |
| 6323660 | Hypothetical ORF |
| 6323665 | Mitochondrial protein, forms a heterodimer complex with Mto1p that performs the 5-carboxymethylaminomethyl modification of the wobble uridine base in mitochondrial tRNAs; similar to human GTPBP3 |
| 6323688 | TyB Gag-Pol protein; proteolytically processed to make the Gag, RT, PR, and IN proteins that are required for retrotransposition |
| 6323693 | Protein required for maturation of the 25S and 5.8S ribosomal RNAs; constituent of 66S pre-ribosomal particles; homologous to mammalian Bop1 |
| 6323694 | TyB Gag-Pol protein; proteolytically processed to make the Gag, RT, PR, and IN proteins that are required for retrotransposition |
| 6323699 | Subunit of vacuolar-ATPase V0 domain, one of two isoforms (Stv1p and Vph1p); Stv1p is located in V-ATPase complexes of the Golgi and endosomes while Vph1p is located in V-ATPase complexes of the vacuole |
| 6323703 | Ferro-O2-oxidoreductase required for high-affinity iron uptake and involved in mediating resistance to copper ion toxicity, belongs to class of integral membrane multicopper oxidases |
| 6323706 | Cleavage and polyadenylation factor I (CF I) component involved in cleavage and polyadenylation of mRNA 3' ends; bridges interaction between Rna15p and Hrp1p in the CF I complex |
| 6323726 | ATP-dependent RNA helicase of the SFI superfamily, required for nonsense mediated mRNA decay and for efficient translation termination at nonsense codons |
| 6323729 | Mitochondrial alcohol dehydrogenase isozyme III; involved in the shuttling of mitochondrial NADH to the cytosol under anaerobic conditions and ethanol production |
| 6323735 | Permease of basic amino acids in the vacuolar membrane |
| 6323736 | Component, with Afg3p, of the mitochondrial inner membrane m-AAA protease that mediates degradation of misfolded or unassembled proteins and is also required for correct assembly of mitochondrial enzyme complexes |
| 6323739 | Actin cortical patch component; probable binding site on actin lies on front surface of subdomains 3 and 4 |
| 6323751 | Protein kinase with similarityto serine/threonine protein kinase Ypk1p; functionally redundant with YPK1 at the genetic level; participates in a signaling pathway required for optimal cell wall integrity; homolog of mammalian kinase SGK |
| 6323755 | Acetolactate synthase, catalyses the first common step in isoleucine and valine biosynthesis and is the target of several classes of inhibitors, localizes to the mitochondria; expression of the gene is under general amino acid control |
| 6323756 | One of two type I myosins; contains proline-rich tail homology 2 (TH2) and SH3 domains; MYO5 deletion has little effect on growth, but myo3 myo5 double deletion causes severe defects in growth and actin cytoskeleton organization |
| 6323757 | Hypothetical ORF |
| 6323760 | Dihydrofolate synthetase, involved in folic acid biosynthesis; catalyzes the conversion of dihydropteroate to dihydrofolate in folate coenzyme biosynthesis |
| 6323776 | Essential DEAH-box ATP-dependent RNA helicase specific to the U3 snoRNP, predominantly nucleolar in distribution, required for 18S rRNA synthesis |
| 6323779 | Essential nuclear protein involved in early steps of ribosome biogenesis; physically interacts with the ribosomal protein Rpl3p |
| 6323787 | GTP-binding protein involved in beta-tubulin (Tub2p) folding; isolated as mutant with increased chromosome loss and sensitivity to benomyl |
| 6323794 | Mitochondrial external NADH dehydrogenase, catalyzes the oxidation of cytosolic NADH; Nde1p and Nde2p are involved in providing the cytosolic NADH to the mitochondrial respiratory chain |
| 6323813 | Co-chaperone for Hsp40p, anchored in the ER membrane; with its homolog Hdj1p promotes ER-associated protein degradation (ERAD) of integral membrane substrates; similar to E. coli DnaJ |
| 6323814 | Non-essential P-type ATPase that is a potential aminophospholipid translocase, localizes to the trans-Golgi, likely involved in protein transport |
| 6323819 | Protein required for mismatch repair in mitosis and meiosis, postmeiotic segregation, and spore viability; forms a complex with Pms1p and Msh2p to repair mismatched DNA; human homolog is associated with hereditary non-polyposis colon cancer |
| 6323832 | Hypothetical ORF |
| 6323837 | SSO1 and SSO2 encode syntaxin homologs (post-Golgi t-SNAREs); act in late stages of secretion; post-Golgi t-SNARE |
| 6323844 | Nucleolar DNA helicase of the RecQ family, involved in maintenance of genome integrity; has similarity to human BLM and WRN helicases implicated in Bloom and Werner syndromes |
| 6323863 | Mitochondrial acetyl-coenzyme A carboxylase, catalyzes the production of malonyl-CoA in mitochondrial fatty acid biosynthesis |
| 6323866 | Hypothetical ORF |
| 37362683 | One of several homologs of bacterial chaperone DnaJ, located in the ER lumen where it cooperates with Kar2p to mediate maturation of proteins |
| 6323872 | Protein serine kinase with similarity to human SRPK1, which is a serine kinase that specifically phosphoryates arginine-serine rich domains found in the SR family of splicing factors |
| 6323880 | Subunit of a complex with Rad50p and Xrs2p (RMX complex) that functions in repair of DNA double-strand breaks and in telomere stability, exhibits nuclease activity that appears to be required for RMX function; widely conserved |
| 6323890 | Ribonuclease H1, removes RNA primers during Okazaki fragment synthesis; degrades RNA attached to the 5'-end of a DNA strand |
| 6323903 | Long chain fatty acyl-CoA synthetase |
| 6323917 | 115 kD regulatory subunit of trehalose-6-phosphate synthase/phosphatase complex |
| 6323934 | Hypothetical ORF |
| 6323947 | ATP-dependent RNA helicase; localizes to both the nuclear periphery and nucleolus; highly enriched in nuclear pore complex fractions; constituent of 66S pre-ribosomal particles |
| 6323948 | Hypothetical ORF |
| 6323954 | Component of serine palmitoyltransferase, responsible along with Lcb2p for the first committed step in sphingolipid synthesis, which is the condensation of serine with palmitoyl-CoA to form 3-ketosphinganine |
| 6323959 | Mitochondrial inner membrane transporter, exports mitochondrially synthesized precursors of iron-sulfur (Fe/S) clusters to the cytosol; member of the ATP-binding cassette (ABC) transporter family |
| 6323961 | Glucose-repressible alcohol dehydrogenase II, catalyzes the conversion of ethanol to acetaldehyde; involved in the production of certain carboxylate esters; regulated by ADR1 |
| 6323962 | Ubiquitin-specific protease that may play a role in ubiquitin precursor processing |
| 6323968 | Karyopherin/importin that interacts with the nuclear pore complex; acts as the nuclear import receptor for specific proteins, including Pdr1p, Yap1p, Ste12p, and Aft1p |
| 6323975 | Hypothetical ORF |
| 6323980 | NADPH-dependent cinnamyl alcohol dehydrogenase family member with broad substrate specificity; may be involved in fusel alcohol synthesis or in aldehyde tolerance |
| 6322967 | High-affinity S-methylmethionine permease, required for utilization of S-methylmethionine as a sulfur source; has similarity to S-adenosylmethionine permease Sam3p |
| 6322980 | Bile transporter of the ATP-binding cassette (ABC) family; has similarity to a mammalian bile transporter |
| 6322992 | Splicing factor associated with the spliceosome; contains a U-box, a motif found in a class of ubiquitin ligases |
| 6322994 | Putative ATPase of the AAA family, required for export of pre-ribosomal large subunits from the nucleus; distributed between the nucleolus, nucleoplasm, and nuclear periphery depending on growth conditions |
| 6322997 | ER membrane localized phosphoryltransferase that adds phosphoethanolamine onto the third mannose residue of the glycosylphosphatidylinositol (GPI) anchor precursor; similar to human PIG-O protein |
| 6322999 | Hypothetical ORF |
| 6323000 | Proton-motive-force-dependent multidrug transporter of the major facilitator superfamily; able to transport eight different compounds, including polyamines, quinidine, cycloheximide, and nystatin; involved in excess spermidine detoxification |
| 6323002 | Heat shock protein that cooperates with Ydj1p (Hsp40) and Ssa1p (Hsp70) to refold and reactivate previously denatured, aggregated proteins; responsive to stresses including |
| 6323009 | Nonessential putative protein kinase of unknown cellular role; member of the LAMMER family of protein kinases, which are serine/threonine kinases also capable of phosphorylating tyrosine residues |
| 6323011 | Cytoplasmic aspartyl-tRNA synthetase, homodimeric enzyme that catalyzes the specific aspartylation of tRNA(Asp); class II aminoacyl tRNA synthetase; binding to its own mRNA may confer autoregulation |
| 6323014 | ABC type transmembrane transporter of MRP/CFTR family, found in vacuolar membrane, involved in the transport of unconjugated bilirubin and in heavy metal detoxification via glutathione conjugates, along with Ycf1p |
| 6323019 | Plasma membrane associated protein phosphatase involved in the general stress response; required along with binding partner Whi2p for full activation of STRE-mediated gene expression, possibly through dephosphorylation of Msn2p |
| 6323021 | Nucleolar DEAD-box protein required for ribosome assembly and function, including synthesis of 60S ribosomal subunits; constituent of 66S pre-ribosomal particles |
| 6323028 | Dynamin-related GTPase required for mitochondrial fission and the maintenance of mitochondrial morphology, assembles on the cytoplasmic face of mitochondrial tubules at sites at which division will occur; also participates in endocytosis |
| 6323047 | Functionally redundant Psr1p homolog, a plasma membrane phosphatase involved in the general stress response; required with Psr1p and Whi2p for full activation of STRE-mediated gene expression, possibly through dephosphorylation of Msn2p |
| 6323050 | Essential protein involved in RNA metabolism, one of two yeast homologs (with Yhr087wp) of the human protein SBDS responsible for autosomal recessive Shwachman-Bodian-Diamond Syndrome, also conserved in Archaea |
| 6323054 | Sed5p is a t-SNARE (soluble NSF attachment protein receptor) required in ER to Golgi transport |
| 6323060 | Single-stranded DNA-dependent ATPase, involved in postreplication repair; contains RING finger domain |
| 6323062 | Putative metal transporter, Nramp homolog, homolog of SMF1 and SMF2 |
| 6323063 | Protein required for DNA mismatch repair in mitosis and meiosis; involved in the repair of mutational intermediates; forms a complex with Pms1p and Msh1p to repair mismatched DNA |
| 6323064 | Ty ORF |
| 6323110 | Galactose permease, required for utilization of galactose; also able to transport glucose |
| 6323115 | Subunit of the condensin complex, which reorganizes chromosomes during cell division, forms a stable complex with Smc2p that has ATP-hydrolyzing and DNA-binding activity and promotes knotting of circular DNA; potential Cdc28p substrate |
| 6323118 | putative alanine transaminase (glutamyc pyruvic transaminase) |
| 6323119 | Putative homolog of E. coli DnaJ, closely related to Ydj1p |
| 6323121 | High affinity sulfate permease; sulfate uptake is mediated by specific sulfate transporters Sul1p and Sul2p, which control the concentration of endogenous activated sulfate intermediates |
| 6323125 | Serine/threonine protein kinase involved in regulation of exocytosis; localizes to the cytoplasmic face of the plasma membrane; closely related to Kin1p |
| 6323142 | Mitogen-activated protein kinase involved in osmoregulation via three independent osmosensors; mediates the recruitment and activation of RNA Pol II at Hot1p-dependent promoters; localization regulated by Ptp2p and Ptp3p |
| 6323158 | Nucleolar protein, specifically associated with the U3 snoRNA, part of the large ribonucleoprotein complex known as the small subunit (SSU) processome, required for 18S rRNA biogenesis, part of the active pre-rRNA processing complex |
| 6323167 | Na+/H+ antiporter involved in sodium and potassium efflux through the plasma membrane; required for alkali cation tolerance at acidic pH |
| 6323177 | Vacuolar peripheral membrane protein that promotes vesicular docking/fusion reactions in conjunction with SNARE proteins, required for vacuolar biogenesis, forms complex with Pep5p that mediates protein transport to the vacuole |
| 52788576 | Cell-wall L-asparaginase II, involved in asparagine catabolism; expression is induced during nitrogen starvation; four copies of ASP3 are present in the genome reference strain S288C |
| 52788579 | Cell-wall L-asparaginase II, involved in asparagine catabolism; expression is induced during nitrogen starvation; four copies of ASP3 are present in the genome reference strain S288C |
| 7839185 | TyB Gag-Pol protein; proteolytically processed to make the Gag, RT, PR, and IN proteins that are required for retrotransposition |
| 52788581 | Cell-wall L-asparaginase II, involved in asparagine catabolism; expression is induced during nitrogen starvation; four copies of ASP3 are present in the genome reference strain S288C |
| 52788584 | Cell-wall L-asparaginase II, involved in asparagine catabolism; expression is induced during nitrogen starvation; four copies of ASP3 are present in the genome reference strain S288C |
| 6323192 | Smaller subunit of the mitochondrial processing protease, essential processing enzyme that cleaves the N-terminal targeting sequences from mitochondrially imported proteins |
| 6323217 | Half-type ATP-binding cassette (ABC) transporter of the inner mitochondrial membrane, mediates export of peptides generated upon proteolysis of mitochondrial proteins, plays a role in the regulation of cellular resistance to oxidative stress |
| 6323226 | Component of the small (ribosomal) subunit (SSU) processosome that contains U3 snoRNA; similar to microtubule binding proteins |
| 6323239 | Involved in mitotic induction; G(sub)2-specific B-type cyclin |
| 6323241 | Gamma-tubulin, involved in nucleating microtubules from both the cytoplasmic and nuclear faces of the spindle pole body |
| 6323251 | Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA |
| 7839187 | TyB Gag-Pol protein; proteolytically processed to make the Gag, RT, PR, and IN proteins that are required for retrotransposition |
| 6323261 | Kynureninase, required for biosynthesis of nicotinic acid from tryptophan via kynurenine pathway |
| 6323266 | Plasma membrane transporter responsible for the uptake of thiamine, member of the major facilitator superfamily of transporters; mutation of human ortholog causes thiamine-responsive megaloblastic anemia |
| 6323269 | Phosphatidylinositol 3-kinase responsible for the synthesis of phosphatidylinositol 3-phosphate; forms membrane-associated signal transduction complex with Vps15p to regulate protein sorting; similar to p110 subunit of mammalian PI 3-kinase |
| 6323275 | Subunit of a palmitoyltransferase, composed of Erf2p and Shr5p, that adds a palmitoyl lipid moiety to Ras2p through a thioester linkage; mutants partially mislocalize Ras2p to the vacuole |
| 6323277 | Protein kinase involved in the response to oxidative stress; identified as suppressor of S. pombe cell cycle checkpoint mutations |
| 6323278 | stimulates the binding of aminoacyl-tRNA (AA-tRNA) to ribosomes by releasing EF-1 alpha from the ribosomal complex; contains two ABC cassettes, and binds and hydrolyses ATP; EF-3 (translational elongation factor 3) |
| 6323282 | Hypothetical ORF |
| 6323287 | Glycogen synthase, similar to Gsy1p; expression induced by glucose limitation, nitrogen starvation, heat shock, and stationary phase; activity regulated by cAMP-dependent, Snf1p and Pho85p kinases as well as by the Gac1p-Glc7p phosphatase |
| 6323291 | Ras-like GTP binding protein involved in the secretory pathway, required for fusion of endosome-derived vesicles with the late Golgi; has similarity to the human GTPase, Rab6 |
| 6323302 | Protein required for accurate sister chromatid segregation |
| 6323304 | Component of the hexameric MCM complex, which is important for priming origins of DNA replication in G1 and becomes an active ATP-dependent helicase that promotes DNA melting and elongation when activated by Cdc7p-Dbf4p in S-phase |
| 6323306 | ATP-dependent RNA helicase of the DEAD-box family involved in biogenesis of the 60S ribosomal subunit |
| 6323307 | subunit of Polyadenylation factor I (PF I) |
| 6323322 | Beta subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a negative regulator of GCN4 expression |
| 6323324 | GTP binding protein (mammalian Ranp homolog) involved in the maintenance of nuclear organization, RNA processing and transport; regulated by Prp20p, Rna1p, Yrb1p, Yrb2p, Yrp4p, Yrb30p, Cse1p and Kap95p; yeast Gsp2p homolog |
| 6323330 | Gamma-glutamyltranspeptidase, major glutathione-degrading enzyme; expression induced mainly by nitrogen starvation |
| 6323335 | Aconitase, required for the tricarboxylic acid (TCA) cycle and also independently required for mitochondrial genome maintenance; component of the mitochondrial nucleoid; mutation leads to glutamate auxotrophy |
| 6323336 | Phosphatidylinositol-4-kinase that functions in the Pkc1p protein kinase pathway; required for normal vacuole morphology, cell wall integrity, and actin cytoskeleton organization |
| 6323338 | Chitin deacetylase, together with Cda2p involved in the biosynthesis ascospore wall component, chitosan; required for proper rigidity of the ascospore wall |
| 6323346 | Component of the septin ring of the mother-bud neck that is required for cytokinesis; septins recruit proteins to the neck and can act as a barrier to diffusion at the membrane, and they comprise the 10nm filaments seen with EM |
| 6323354 | Involved in chromatin modeling, cell cycle progression; homolog of Snf5p, member of the chromatin remodeling complex, RSC |
| 6323363 | O-glycosylated plasma membrane protein that acts as a sensor for cell wall integrity signaling and activates the pathway; interacts with Rom2p, a guanine nucleotide exchange factor for Rho1p, and with cell integrity pathway protein Zeo1p |
| 6323375 | Putative 1,3-beta-glucanosyltransferase, has similarity to Gas1p |
| 6323377 | Hypothetical ORF |
| 6323379 | Karyopherin beta, forms a dimeric complex with Srp1p (Kap60p) that mediates nuclear import of cargo proteins via a nuclear localization signal (NLS), interacts with nucleoporins to guide transport across the nuclear pore complex |
| 6323383 | Nit protein, one of two proteins in S. cerevisiae with similarity to the Nit domain of NitFhit from fly and worm and to the mouse and human Nit protein which interacts with the Fhit tumor suppressor; nitrilase superfamily member |
| 6323387 | Acetohydroxyacid reductoisomerase, mitochondrial protein involved in branched-chain amino acid biosynthesis, also required for maintenance of wild-type mitochondrial DNA |
| 6323391 | Adenylosuccinate lyase, catalyzes two steps in the 'de novo' purine nucleotide biosynthetic pathway |
| 6323394 | Signal transducing MEK kinase involved in pheromone response and pseudohyphal/invasive growth pathways, where it phosphorylates Ste7p, and the high osmolarity response pathway, via phosphorylation of Pbs2p; regulated by Ste20p and Ste50p |
| 6323401 | Mitochondrial hsp70-type molecular chaperone, involved in the synthesis and assembly of iron/sulfur clusters into proteins |
| 6323404 | Elongase III synthesizes 20-26-carbon fatty acids from C18-CoA primers; involved in fatty acid biosynthesis |
| 6323414 | Mitochondrial leucyl-tRNA synthetase, also has a direct role in splicing of several mitochondrial group I introns; indirectly required for mitochondrial genome maintenance |
| 6323416 | Subunit of RNA polymerase II elongator histone acetyltransferase complex, involved in maintaining its structural integrity; negatively regulates exocytosis independent of transcription, homolog of human familial dysautonomia (FD) protein |
| 6323418 | Activator of Fab1p; essential for the regulated synthesis of PtdIns(3,5)P(2), for control of trafficking of some proteins to the vacuole lumen via the MVB, and for maintenance of vacuole size and acidity |
| 6323419 | Protein of unknown function, similar to Rei1p but not involved in bud growth; contains dispersed C2H2 zinc finger domains |
| 6323428 | vacuolar sorting protein essential for vacuolar morphogenesis and function; involved in vacuolar protein targeting |
| 6323429 | ATPase of the CDC48/PAS1/SEC18 (AAA) family, forms a hexameric complex; may be involved in degradation of aberrant mRNAs |
| 6323430 | blocks translation of non-poly(A) mRNAs; antiviral protein, putative helicase |
| 6323433 | Dihydrouridine synthase, member of a widespread family of conserved proteins including Smm1p, Dus1p, and Dus4p; contains a consensus oleate response element (ORE) in its promoter region |
| 6323437 | Dihydrouridine synthase, member of a widespread family of conserved proteins including Smm1p, Dus1p, and Dus3p |
| 6323441 | Possible U3 snoRNP protein involved in maturation of pre-18S rRNA, based on computational analysis of large-scale protein-protein interaction data |
| 6323442 | Homologous to S. pombe asp1+ |
| 7839190 | TyB Gag-Pol protein; proteolytically processed to make the Gag, RT, PR, and IN proteins that are required for retrotransposition |
| 6323451 | Hypothetical ORF |
| 6323460 | Coronin, cortical actin cytoskeletal component that associates with the Arp2p/Arp3p complex to regulate its activity |
| 6323464 | Inosine monophosphate dehydrogenase, catalyzes the first step of GMP biosynthesis, member of a four-gene family in S. cerevisiae, constitutively expressed |
| 6323483 | One of two isozymes of HMG-CoA reductase that convert HMG-CoA to mevalonate, a rate-limiting step in sterol biosynthesis; overproduction induces assembly of peripheral ER membrane arrays and short nuclear-associated membrane stacks |
| 6322636 | WD repeat protein required for ubiquitin-mediated protein degradation, forms complex with Cdc48p, plays a role in controlling cellular ubiquitin concentration; also promotes efficient NHEJ in postdiauxic/stationary phase |
| 6322637 | Lipid phosphoinositide phosphatase of the ER and Golgi, involved in protein trafficking and secretion |
| 42759860 | putative protein/phosphatidylinositol kinase involved in signaling activation of translation initiation, distribution of the actin cytoskeleton, and meiosis; phosphatidylinositol kinase homolg |
| 6322651 | AAA-family ATPase peroxin required for peroxisome biogenesis, contains two 230 amino acid ATP-binding AAA cassettes, upregulated in anaerobiosis; Pex1p and Pex6p interact via their N-terminal AAA-cassettes |
| 6322659 | Component of the RAM signaling network that is involved in regulation of Ace2p activity and cellular morphogenesis, interacts with Kic1p and Sog2p, localizes to sites of polarized growth during budding and during the mating response |
| 6322660 | Subunit of a heterodimeric peroxisomal ATP-binding cassette transporter complex (Pxa1p-Pxa2p), required for import of long-chain fatty acids into peroxisomes; similarity to human adrenoleukodystrophy transporter and ALD-related proteins |
| 6322669 | Golgi membrane protein with similarity to mammalian CASP; genetic interactions with GOS1 (encoding a Golgi snare protein) suggest a role in Golgi function |
| 6322675 | involved in splicing; U5 snRNP-specific protein related to EF-2 |
| 6322682 | Involved in nutrient control of cell growth and division; cAMP-dependent protein kinase catalytic subunit |
| 6322683 | Protein involved in glycosylphosphatidylinositol (GPI) anchor synthesis; multimembrane-spanning protein that localizes to the endoplasmic reticulum; highly conserved among eukaryotes |
| 9755335 | Zinc-dependent metallopeptidase yscII, may have a role in obtaining leucine from dipeptide substrates; sequence coordinates have changed since RT-PCR analysis showed that the adjacent ORF YKL158W comprises the 5' exon of APE2/YKL157W |
| 6322704 | One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; required for optimal CDC20 transcription; interacts with Rpn12p and the E3 ubiquitin-protein ligase Ubr1p |
| 6322710 | Catalytic (alpha) subunit of C-terminal domain kinase I (CTDK-I), which phosphorylates the C-terminal repeated domain of the RNA polymerase II large subunit (Rpo21p) to affect both transcription and pre-mRNA 3' end processing |
| 6322714 | Beta-adaptin, large subunit of the clathrin-associated protein (AP-1) complex |
| 6322715 | Mitochondrial intermediate peptidase, cleaves N-terminal residues of a subset of proteins upon import, after their cleavage by mitochondrial processing peptidase (Mas1p-Mas2p); may contribute to mitochondrial iron homeostasis |
| 6322720 | One of two type I myosins; localizes to actin cortical patches; deletion of MYO3 has little effect on growth, but myo3 myo5 double deletion causes severe defects in growth and actin cytoskeleton organization |
| 6322723 | Serine/threonine protein kinase required for receptor-mediated endocytosis; involved in sphingolipid-mediated and cell integrity signaling pathways; localized to the bud neck, cytosol and plasma membrane; homolog of mammalian kinase SGK |
| 6322733 | Protein kinase with a possible role in MAP kinase signaling in the pheromone response pathway |
| 6322735 | Major apurinic/apyrimidinic endonuclease, 3'-repair diesterase involved in repair of DNA damage by oxidation and alkylating agents; controls spontaneous mutations |
| 6322746 | Vacuolar aminopeptidase, often used as a marker protein in studies of autophagy and cytosol to vacuole targeting (CVT) pathway |
| 6322749 | Hypothetical ORF |
| 6322755 | Essential nuclear protein; putative spliceosomal component involved in mRNA splicing, based on computational analysis of large-scale protein-protein interaction data |
| 6322769 | Translation elongation factor EF-1gamma |
| 6322771 | not believed to act as a kinesin, colocalizes with Myo2p; kinesin heavy chain homolog |
| 6322772 | Predominantly nucleolar DEAH-box RNA helicase, required for 18S rRNA synthesis |
| 6322777 | Molecular chaperone of the endoplasmic reticulum lumen, involved in polypeptide translocation and folding; member of the Hsp70 family; localizes to the lumen of the ER; regulated by the unfolded protein response pathway |
| 6322796 | RNAPII degradation factor, forms a complex with Rad26p in chromatin, enables ubiquitination and proteolysis of RNAPII |
| 6322823 | Mitochondrial malic enzyme, catalyzes the oxidative decarboxylation of malate to pyruvate, which is a key intermediate in sugar metabolism and a precursor for synthesis of several amino acids |
| 6322824 | TFIIE large subunit, involved in recruitment of RNA polymerase II to the promoter, activation of TFIIH, and promoter opening |
| 6322831 | Protein essential for cell growth and replication of M dsRNA virus; contains four beta-transducin repeats |
| 6322833 | Alpha subunit of both the farnesyltransferase and type I geranylgeranyltransferase that catalyze prenylation of proteins containing a CAAX consensus motif; essential protein required for membrane localization of Ras proteins and a-factor |
| 6322835 | Hexameric DNA polymerase alpha-associated DNA helicase A involved in lagging strand DNA synthesis; contains single-stranded DNA stimulated ATPase and dATPase activities; replication protein A stimulates helicase and ATPase activities |
| 6322853 | involved in vacuolar protein sorting and normal organization of intracellular membranes; probably required for membrane-protein retention in a late Golgi compartment; putative GTP-binding protein; similar to mammalian Mx proteins |
| 6322854 | Poly(A) polymerase, one of three factors required for mRNA 3'-end polyadenylation, forms multiprotein complex with polyadenylation factor I (PF I), also required for mRNA nuclear export; may also polyadenylate rRNAs |
| 6322864 | Protein of unknown function, has similarity to Pry1p and Pry3p and to the plant PR-1 class of pathogen related proteins |
| 6322869 | Hypothetical ORF |
| 6322876 | Putative ATP-dependent RNA helicase of the DEAD-box family involved in ribosomal biogenesis |
| 6322883 | Phospholipase D, catalyzes the hydrolysis of phosphatidylcholine, producing choline and phosphatidic acid; involved in Sec14p-independent secretion; required for meiosis and spore formation; differently regulated in secretion and meiosis |
| 37362674 | Putative glycoprotease that interacts with Bud32p, which is a member of the novel protein kinase piD261 family |
| 6322892 | General amino acid permease; localization to the plasma membrane is regulated by nitrogen source |
| 6322895 | Youth, involved in determining yeast longevity; involved in cell growth |
| 6322903 | Component of the Trk1p-Trk2p potassium transport system |
| 6322904 | Hypothetical ORF |
| 6322907 | Cytoplasmic heavy chain dynein, microtubule motor protein, required for anaphase spindle elongation; involved in spindle assembly, chromosome movement, and spindle orientation during cell division, targeted to microtubule tips by Pac1p |
| 42759862 | tRNA methyltransferase, 5-methylates the uridine residue at position 54 of tRNAs and may also have a role in tRNA stabilization or maturation; previously thought to be an endo-exonuclease |
| 6322914 | Mannosyltransferase involved in N-linked protein glycosylation; member of the KRE2/MNT1 mannosyltransferase family |
| 6322919 | Mitochondrial cytochrome-c peroxidase; degrades reactive oxygen species in mitochondria, involved in the response to oxidative stress |
| 6322922 | S-adenosyl-L-methionine uroporphyrinogen III transmethylase, involved in sulfate assimilation, methionine metabolism, and siroheme biosynthesis |
| 6322932 | Protein required for cell viability |
| 6322937 | GTP binding protein with sequence similarity to the elongation factor class of G proteins, EF-1alpha and Sup35p; associates with Dom34p, and shares a similar genetic relationship with genes that encode ribosomal protein components |
| 6322939 | RNA helicase in the DEAH-box family involved in the second catalytic step of splicing, exhibits ATP-dependent RNA unwinding activity |
| 6322945 | Suppressor of mutant AC40 subunit of RNA polymerase I and III; nucleolar protein that is immunologically and structurally related to rat Nopp140, a nonribosomal protein of the nucleolus and coiled bodies. |
| 6322946 | Integral membrane peptide transporter, mediates transport of di- and tri-peptides; conserved protein that contains 12 transmembrane domains; PTR2 expression is regulated by the N-end rule pathway via repression by Cup9p |
| 6322956 | Putative transporter of the multidrug resistance-associated protein (MRP) subfamily; adjacent ORFs YKR103W and YKR104W are merged in different strain backgrounds. |
| 6322958 | Hypothetical ORF |
| 6324000 | Peroxisomal membrane AAA-family ATPase peroxin required for peroxisome assembly, contains two 230 amino acid ATP-binding AAA cassettes, interacts with Pex1p |
| 6324002 | Glycosylphosphatidylinositol (GPI)-anchored cell wall endoglucanase required for proper cell separation after cytokinesis, expression is activated by Swi5p and tightly regulated in a cell cycle-dependent manner |
| 6324003 | Palmitoyltransferase for Vac8p, one of three yeast DHHC-cysteine rich domain proteins (Pfa3p, Erf2p, Akr1p) with palmitoyltransferase activity; required for vacuolar integrity under stress conditions |
| 6324005 | Protein required for efficient mating, member of a family of eukaryotic proteins that contain a domain homologous to Sac1p |
| 6324022 | Protein serine/threonine/tyrosine (dual-specificity) kinase involved in control of chromosome segregation and in regulating entry into meiosis; related to mammalian glycogen synthase kinases of the GSK-3 family |
| 6324031 | Involved in localizing cell growth with respect to the septin ring; protein kinase, homologous to Ste20p, interacts with CDC42 |
| 6324037 | Pseudouridine synthase, catalyzes only the formation of pseudouridine-55 (Psi55), a highly conserved tRNA modification, in mitochondrial and cytoplasmic tRNAs; PUS4 overexpression leads to translational derepression of GCN4 (Gcd- phenotype) |
| 6324039 | Subunit of heteropentameric Replication factor C (RF-C), which is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor for DNA polymerases delta and epsilon |
| 6324042 | Gamma subunit of coatomer, a heptameric protein complex that together with Arf1p forms the COPI coat; involved in ER to Golgi transport of selective cargo |
| 7839194 | TyB Gag-Pol protein; proteolytically processed to make the Gag, RT, PR, and IN proteins that are required for retrotransposition |
| 6324046 | cell wall integrity and stress response component 2; Putative integral membrane protein containing novel cysteine motif. Similarity to SLG1 (WSC1), WSC3 and WSC4 |
| 6324049 | C-14 sterol reductase, acts in ergosterol biosynthesis; mutants accumulate the abnormal sterol ignosterol (ergosta-8,14 dienol), and are viable under anaerobic growth conditions but inviable on rich medium under aerobic conditions |
| 6324055 | Putative hydroxyisocaproate dehydrogenase |
| 6324059 | Basic amino acid transporter, involved in uptake of cationic amino acids |
| 6324061 | Lysine permease; one of three amino acid permeases (Alp1p, Can1p, Lyp1p) responsible for uptake of cationic amino acids |
| 6324062 | Phosphatidylinositol 4-kinase; catalyzes first step in the biosynthesis of phosphatidylinositol-4,5-biphosphate; may control cytokineses through the actin cytoskeleton |
| 6324067 | Catalytic subunit of DNA polymerase epsilon, one of the major chromosomal DNA replication polymerases characterized by processivity and proofreading exonuclease activity; also involved in DNA synthesis during DNA repair |
| 6324079 | Subunit of MRX complex, with Mre11p and Xrs2p, involved in processing double-strand DNA breaks in vegetative cells, initiation of meiotic DSBs, telomere maintenance, and nonhomologous end joining |
| 6324082 | Protein required for cell viability |
| 6324091 | Subtilisin-like protease (proprotein convertase), a calcium-dependent serine protease involved in the activation of proproteins of the secretory pathway |
| 37362688 | Cysteine protease required for autophagy; cleaves Atg8p to a form required for autophagosome and Cvt vesicle generation; mediates attachment of autophagosomes to microtubules through interactions with Tub1p and Tub2p |
| 6324111 | Protein with DNA-dependent ATPase and ssDNA annealing activities involved in maintenance of genome; interacts functionally with DNA polymerase delta; homolog of human Werner helicase interacting protein (WHIP) |
| 6324113 | DNA-binding protein involved in either activation or repression of transcription, depending on binding site context; also binds telomere sequences and plays a role in telomeric position effect (silencing) and telomere structure |
| 6324126 | Peroxisomal 2,4-dienoyl-CoA reductase, auxiliary enzyme of fatty acid beta-oxidation; homodimeric enzyme required for growth and sporulation on petroselineate medium; expression induced during late sporulation and in the presence of oleate |
| 6324128 | Nuclear protein of unknown function; deletion results in sensitivity to anticancer drugs oxaliplatin and cisplatin, but not mitomycin C; deletion is synthetically lethal with a chitin synthase (CHS1) null mutant |
| 6324137 | Chitin synthase I, requires activation from zymogenic form in order to catalyze the transfer of N-acetylglucosamine (GlcNAc) to chitin; required for repairing the chitin septum during cytokinesis; transcription activated by mating factor |
| 6324146 | Protein kinase that stabilizes several plasma membrane amino acid transporters by antagonizing their ubiquitin-mediated degradation |
| 6324160 | Phosphatidylserine decarboxylase of the mitochondrial inner membrane, converts phosphatidylserine to phosphatidylethanolamine |
| 6324166 | Cytoplasmic GTPase involved in biogenesis of the 60S ribosome; has similarity to translation elongation factor 2 (Eft1p and Eft2p) |
| 6324168 | Protein kinase involved in cell wall biosynthesis; required for efficient apical growth, proper mating projection morphology, bipolar bud site selection in diploid cells, and cell separation |
| 6324187 | Ammonium permease involved in regulation of pseudohyphal growth; belongs to a ubiquitous family of cytoplasmic membrane proteins that transport only ammonium (NH4+); expression is under the nitrogen catabolite repression regulation |
| 6324191 | Adenylyl cyclase-associated protein; N-terminal domain appears to be involved in cellular responsiveness to RAS |
| 6324197 | Essential protein of unknown function; heterozygous mutant shows haploinsufficiency in K1 killer toxin resistance |
| 42742307 | Cholinephosphotransferase, required for phosphatidylcholine biosynthesis and for inositol-dependent regulation of EPT1 transcription |
| 6324208 | Translocase of Outer Mitochondrial membrane; 70 kDa mitochondrial specialized import receptor of the outer membrane |
| 6324212 | Malate synthase, enzyme of the glyoxylate cycle, involved in utilization of non-fermentable carbon sources; expression is subject to carbon catabolite repression; localizes in peroxisomes during growth in oleic acid medium |
| 6324217 | Essential ATP-dependent RNA helicase of the DEAD-box protein family, involved in nonsense-mediated mRNA decay and rRNA processing |
| 6324224 | Phosphatidylinositol 4,5-bisphosphate 5-phosphatase, synaptojanin-like protein with an N-terminal Sac1 domain, plays a role in endocytosis; hyperosmotic stress causes translocation to actin patches |
| 6324225 | Alpha-isopropylmalate synthase (2-isopropylmalate synthase); the main isozyme responsible for the first step in the leucine biosynthesis pathway |
| 6324227 | Catalytic subunit of the DNA polymerase alpha-primase complex, required for the initiation of DNA replication during mitotic DNA synthesis and premeiotic DNA synthesis |
| 6324237 | Putative S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family |
| 6324241 | Essential type II topoisomerase, catalyzes topology changes in DNA via transient breakage and rejoining of phosphodiester bonds in the DNA backbone; localizes to axial cores in meiosis |
| 46562124 | ATP-binding protein required for mismatch repair in mitosis and meiosis; functions as a heterodimer with Mlh1p, binds double- and single-stranded DNA via its N-terminal domain, similar to E. coli MutL |
| 6324252 | Putative chaperone of the HSP40 (DNAJ) family; overexpression interferes with propagation of the [Psi+] prion |
| 6324256 | Mitochondrial lysine-tRNA synthetase, required for import of both aminoacylated and deacylated forms of tRNA(Lys) into mitochondria |
| 6324258 | Dihydrolipoamide acetyltransferase component (E2) of pyruvate dehydrogenase complex, which catalyzes the oxidative decarboxylation of pyruvate to acetyl-CoA |
| 6324264 | Plasma membrane transporter of the major facilitator superfamily that confers resistance to short-chain monocarboxylic acids and quinidine |
| 6324265 | yeast dnaJ homolog (nuclear envelope protein); heat shock protein |
| 6324268 | Probable RNA m(5)C methyltransferase, essential for processing and maturation of 27S pre-rRNA and large ribosomal subunit biogenesis; localized to the nucleolus; constituent of 66S pre-ribosomal particles |
| 6324279 | Probable component of COPII coated vesicles that binds to Sec23p; similar to and functionally redundant with Sec24p, but expressed at low levels; involved in ER to Golgi transport and in autophagy |
| 6324283 | Similar to human LTA4 hydrolase but in vivo substrates not yet defined. |
| 6324301 | Transcription factor that activates transcription of genes involved in stress response; nuclear localization is positively regulated by calcineurin-mediated dephosphorylation |
| 6324306 | Non-essential protein with similarity to S. pombe hypothetical protein E349594 |
| 6324314 | Translational elongation factor EF-3; paralog of YEF3 and member of the ABC superfamily; stimulates EF-1 alpha-dependent binding of aminoacyl-tRNA by the ribosome; normally expressed in zinc deficient cells |
| 6324321 | HSP40 family chaperone; sit4 suppressor, dnaJ homolog |
| 6324326 | Nucleolar protein with similarity to large ribosomal subunit L7 proteins; constituent of 66S pre-ribosomal particles; plays an essential role in processing of precursors to the large ribosomal subunit RNAs |
| 6324328 | Citrate synthase, catalyzes the condensation of acetyl coenzyme A and oxaloacetate to form citrate; the rate-limiting enzyme of the TCA cycle; nuclear encoded mitochondrial protein |
| 6324334 | Protein involved in autophagy; E2-like enzyme that plays a role in formation of Atg8p-phosphatidylethanolamine conjugates, which are involved in membrane dynamics during autophagy |
| 6324338 | RNA-dependent ATPase in the DEAH-box family, required for activation of the spliceosome before the first transesterification step in RNA splicing |
| 6324340 | Low-affinity phosphate transporter; deletion of pho84, pho87, pho89, pho90, and pho91 causes synthetic lethality; transcription independent of Pi and Pho4p activity; overexpression results in vigorous growth |
| 6324343 | Acetyl-CoA carboxylase, biotin containing enzyme that catalyzes the carboxylation of acetyl-CoA to form malonyl-CoA; required for de novo biosynthesis of long-chain fatty acids |
| 6324346 | Acyl-CoA |
| 6324354 | Protein involved in bud-site selection; diploid mutants display a random budding pattern instead of the wild-type bipolar pattern |
| 6324356 | Hypothetical ORF |
| 6324358 | Suppressor of Sensor Kinase (SLN1); A MAP kinase kinase kinase; activator of Pbs2p |
| 6324363 | Subunit of the ARP2/3 complex, which is required for the motility and integrity of cortical actin patches; required for cortical localization of calmodulin |
| 6324366 | Essential protein involved in ribosome biogenesis; putative ATP-dependent RNA helicase of the DEAD-box protein family |
| 6324370 | Para hydroxybenzoate |
| 6324375 | Putative protein kinase that, when overexpressed, interferes with pheromone-induced growth arrest; localizes to the cytoplasm; potential Cdc28p substrate |
| 6324383 | Putative ion transporter similar to the major facilitator superfamily of transporters; mutations in membrane-spanning domains permit nonselective cation uptake |
| 6324384 | Putative transmembrane protein involved in the biotin biosynthesis pathway; responsible for uptake of 7-keto 8-aminopelargonic acid; BIO5 is in a cluster of 3 genes (BIO3, BIO4, and BIO5) that mediate biotin synthesis |
| 6324399 | Hypothetical ORF |
| 6322241 | Protein of unknown function, expression is induced during nitrogen limitation |
| 6322245 | Protein of unknown function, transcriptionally activated by Yrm1p along with genes involved in multidrug resistance |
| 6322247 | Protein of unknown function with similarity to hexose transporter family members, expression is induced by low levels of glucose and repressed by high levels of glucose |
| 6322249 | Plasma membrane transporter that transports tetra- and pentapeptides and glutathione; member of the OPT family |
| 6322261 | Hypothetical ORF |
| 6322263 | Low-affinity phosphate transporter; deletion of pho84, pho87, pho89, pho90, and pho91 causes synthetic lethality; transcription independent of Pi and Pho4p activity; overexpression results in vigorous growth |
| 6322264 | Ubiquitin-specific protease present in the nucleus and cytoplasm that cleaves ubiquitin from ubiquitinated proteins |
| 6322266 | Essential ATP-binding protein required for DNA replication, component of the pre-replicative complex (pre-RC) which requires ORC to associate with chromatin and is in turn required for Mcm2-7p DNA association; homologous to S. pombe Cdc18p |
| 6322286 | transcription factor |
| 6322297 | putative catalytic subunit of cAMP-dependent protein kinase |
| 6322307 | Protein involved in vacuolar sorting; retromer complex component |
| 6322320 | Serine-threonine protein kinase that is part of a glucose-sensing system involved in growth control in response to glucose availability; translocates from the cytoplasm to the nucleus and phosphorylates Pop2p in response to a glucose signal |
| 6322322 | Mannosyltransferase of the KTR1 family, involved in protein N-glycosylation; located in the Golgi apparatus |
| 6322331 | Multifunctional carbamoylphosphate synthetase (CPSase)-aspartate transcarbamylase (ATCase) that catalyzes the two first reactions of the pyrimidine pathway; carbamoyl-phophate synthetase, aspartate transcarbamylase, and glutamine amidotransferase |
| 6322333 | MAP kinase kinase that plays a pivotal role in the osmosensing signal-transduction pathway, activated under severe osmotic stress |
| 6322347 | TyB Gag-Pol protein; proteolytically processed to make the Gag, RT, PR, and IN proteins that are required for retrotransposition |
| 6322349 | WD repeat protein that regulates steps in the Dnm1p-dependent process of mitochondrial fission |
| 6322350 | Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo |
| 6322355 | Serine/threonine protein kinase involved in activation of meiosis, associates with Ime1p and mediates its stability, activates Ndt80p; IME2 expression is positively regulated by Ime1p |
| 6322359 | mitochondrial elongation factor G-like protein |
| 6322360 | Gamma glutamylcysteine synthetase, catalyzes the first step in the gamma-glutamyl cycle for glutathione (GSH) biosynthesis; expression induced by oxidants, cadmium, and mercury |
| 6322366 | Mitogen-activated protein (MAP) kinase kinase kinase acting in the protein kinase C signaling pathway, which controls cell integrity; upon activation by Pkc1p phosphorylates downstream kinases Mkk1p and Mkk2p |
| 6322367 | Putative K+/H+ antiporter |
| 6322369 | DNA helicase and DNA-dependent ATPase involved in DNA repair, required for proper timing of commitment to meiotic recombination and the transition from Meiosis I to Meiosis II; potential Cdc28p substrate |
| 37362667 | Protein involved in the inositol acylation of glucosaminyl phosphatidylinositol (GlcN-PI) to form glucosaminyl(acyl)phosphatidylinositol (GlcN(acyl)PI), an intermediate in the biosynthesis of glycosylphosphatidylinositol (GPI) anchors |
| 6322380 | Nuclear actin-related protein involved in chromatin remodeling, component of chromatin-remodeling enzyme complexes |
| 6322383 | Protein of unknown function, has similarity to Pry1p and Pry2p and to the plant PR-1 class of pathogen related proteins |
| 6322387 | Subunit of the multiprotein cohesin complex required for sister chromatid cohesion in mitotic cells; also required, with Rec8p, for cohesion and recombination during meiosis; phylogenetically conserved SMC chromosomal ATPase family member |
| 6322391 | Hypothetical ORF |
| 6322399 | Integral plasma membrane protein involved in the synthesis of the glycosylphosphatidylinositol (GPI) core structure; mutations affect cell wall integrity |
| 6322401 | Arylformamidase, involved in biosynthesis of nicotinic acid from tryptophan via kynurenine pathway; potential Cdc28p substrate |
| 6322402 | Homolog of human CLN3; vacuolar/lysosomal membrane protein |
| 6322411 | Dead-box family ATP dependent helicase required for mRNA export from the nucleus; co-factor of the exosome complex, required for 3' end formation of 5.8S rRNA |
| 6322427 | Putative nucleolar DEAD box RNA helicase; high-copy number suppression of a U14 snoRNA processing mutant suggests an involvement in 18S rRNA synthesis |
| 6322434 | Ribonucleotide-diphosphate reductase (RNR), small subunit; the RNR complex catalyzes the rate-limiting step in dNTP synthesis and is regulated by DNA replication and DNA damage checkpoint pathways via localization of the small subunits |
| 6322446 | Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo |
| 42742256 | Phosphate metabolism; transcription is regulated by PHO system; polyphosphate synthetase (putative) |
| 6322455 | Adenylate cyclase, required for cAMP production and cAMP-dependent protein kinase signaling; involved in cell cycle control and glucose and nitrogen repression of sporulation |
| 6322461 | Component of the SSU processome, which is required for pre-18S rRNA processing, interacts with and controls the stability of Imp3p and Imp4p, essential for viability; similar to human Mpp10p |
| 6322464 | beta-adaptin, large subunit of the clathrin-associated protein complex |
| 6322465 | DNA polymerase III (delta) 55 kDa subunit, essential for cell viability; involved in DNA replication and DNA repair |
| 6322480 | Thioesterase; peroxisomal acyl-CoA thioesterase |
| 6322487 | TyB Gag-Pol protein; proteolytically processed to make the Gag, RT, PR, and IN proteins that are required for retrotransposition |
| 6322489 | TyB Gag-Pol protein; proteolytically processed to make the Gag, RT, PR, and IN proteins that are required for retrotransposition |
| 6322495 | Protein involved in transcription-coupled repair nucleotide excision repair of UV-induced DNA lesions; homolog of human CSB protein |
| 6322497 | Protein with similarity to hect domain E3 ubiquitin-protein ligases, not essential for viability |
| 6322500 | Chloride channel localized to late- or post-Golgi vesicles, involved in iron metabolism; highly homologous to voltage-gated chloride channels in vertebrates |
| 6322509 | NAD kinase, active as a hexamer; enhances the activity of ferric reductase (Fre1p) |
| 6322511 | Fumarate reductase, catalyzes the reduction of fumarate to succinate, required for the reoxidation of intracellular NADH under anaerobic conditions; mutations cause osmotic sensitivity |
| 6322524 | Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo |
| 6322526 | Involved in cell cycle signaling and meiosis, controls cell growth in response to nutrients; phosphatidylinositol kinase homolog |
| 6322528 | Subunit of heteropentameric Replication factor C (RF-C), which is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor for DNA polymerases delta and epsilon |
| 6322532 | Cytoplasmic protein required for cell viability, identified by association with pre-ribosomal particles |
| 6322536 | Component of the septin ring of the mother-bud neck that is required for cytokinesis; septins recruit proteins to the neck and can act as a barrier to diffusion at the membrane, and they comprise the 10nm filaments seen with EM |
| 6322567 | Hypothetical ORF |
| 6322577 | Highly conserved zinc metalloprotease that functions in two steps of a-factor maturation, C-terminal CAAX proteolysis and the first step of N-terminal proteolytic processing; contains multiple transmembrane spans |
| 6322586 | Vps70p |
| 6322592 | Karyopherin, a carrier protein involved in nuclear import of proteins; importin beta homolog |
| 14318438 | Sulfite reductase beta subunit, involved in amino acid biosynthesis, transcription repressed by methionine |
| 6322602 | Hypothetical ORF |
| 6322610 | Cell wall mannoprotein with similarity to Tir1p, Tir2p, Tir3p, and Tir4p; expressed under anaerobic conditions, completely repressed during aerobic growth |
| 6322611 | Cell wall mannoprotein with similarity to Tir1p, Tir2p, Tir3p, and Tir4p; expressed under anaerobic conditions, completely repressed during aerobic growth |
| 6322619 | Sorbitol dehydrogenase; expression is induced in the presence of sorbitol |
| 6324981 | High-affinity S-adenosylmethionine permease, required for utilization of S-adenosylmethionine as a sulfur source; has similarity to S-methylmethionine permease Mmp1p |
| 37362699 | Half-type ATP-binding cassette (ABC) transporter of the inner mitochondrial membrane |
| 6324987 | Phosphoinositide-specific phospholipase C, hydrolyzes phosphatidylinositol 4,5-biphosphate (PIP2) to generate inositol 1,4,5-triphosphate (IP3) and 1,2-diacylglycerol (DAG); involved in kinetochore function and pseudohyphal differentiation |
| 6324989 | Essential 18S rRNA dimethylase, responsible for conserved m6(2)Am6(2)A dimethylation in 3'-terminal loop of 18 S rRNA, part of 90S and 40S pre-particles in nucleolus, involved in pre-ribosomal RNA processing |
| 6324990 | Dicarboxylic amino acid permease, mediates high-affinity and high-capacity transport of L-glutamate and L-aspartate; also a transporter for Gln, Asn, Ser, Ala, and Gly |
| 6324991 | Hypothetical ORF |
| 6324997 | Hydroxymethylpyrimidine phosphate kinase, involved in the last steps in thiamine biosynthesis; member of a gene family with THI20 and THI22; functionally redundant with Thi20p |
| 7839205 | TyB Gag-Pol protein; proteolytically processed to make the Gag, RT, PR, and IN proteins that are required for retrotransposition |
| 6325024 | SSO1 and SSO2 encode syntaxin homologs (post-Golgi t-SNAREs); act in late stages of secretion; post-Golgi t-SNARE |
| 6325025 | Alpha subunit of fatty acid synthetase, which catalyzes the synthesis of long-chain saturated fatty acids; contains beta-ketoacyl reductase and beta-ketoacyl synthase activities |
| 6325029 | UDP-glucose |
| 6325030 | ATP binding cassette family member; Asn/Gln-rich rich region supports [NU+] prion formation, susceptibility to [PSI+] prion induction and aggregation of a fragment of the human Machado-Joseph Disease protein |
| 6325034 | The authentic, non-tagged protein was localized to the mitochondria. |
| 6325039 | Essential conserved nucleolar GTP-binding protein required for synthesis of 40S ribosomal subunits and for processing of the 35S pre-rRNA at sites A0, A1, and A2; interacts with Rcl1p, has similarity to Tsr1p |
| 6325047 | Aurora kinase involved in regulating kinetochore-microtubule attachments, associates with Sli5p, which stimulates Ipl1p kinase activity and promotes its association with the mitotic spindle, potential Cdc28p substrate |
| 6325049 | Hypothetical ORF |
| 6325052 | Protein kinase involved in regulating diverse events including vesicular trafficking, gene expression, DNA repair, and chromosome segregation; binds the CTD of RNA pol II; homolog of mammalian casein kinase 1delta (CK1delta) |
| 6325061 | Delta-like subunit of the yeast AP-3 complex which functions in transport of alkaline phosphatase to the vacuole via the alternate pathway, suppressor of loss of casein kinase 1 function; delta-like subunit of the yeast AP-3 adaptin component of the membrane-associated clathrin assembly complex |
| 6325068 | Mitochondrial NADH kinase, phosphorylates NADH; also phosphorylates NAD(+) with lower specificity; required for the response to oxidative stress |
| 6325078 | Putative protein serine/threonine phosphatase; null mutation enhances efficiency of translational suppressors |
| 6325085 | Heme A |
| 6325086 | Widely conserved NADPH oxidoreductase containing flavin mononucleotide (FMN), homologous to Oye2p with slight differences in ligand binding and catalytic properties; may be involved in sterol metabolism |
| 6325093 | Protein involved in DNA mismatch repair; forms a complex with Mlh1p to promote meiotic crossing-over; mammalian homolog is implicated mammalian microsatellite instability |
| 6325097 | Cytosolic leucyl tRNA synthetase, ligates leucine to the appropriate tRNA |
| 6325102 | Kinesin-related motor protein involved in mitotic spindle positioning |
| 6325103 | Vacuolar aspartyl protease (proteinase A), required for the posttranslational precursor maturation of vacuolar proteinases; synthesized as a zymogen, self-activates |
| 6325104 | Protein kinase, required for cell-cycle arrest in response to DNA damage; activated by trans autophosphorylation when interacting with hyperphosphorylated Rad9p |
| 6325106 | Splicing factor that is found in the Cef1p subcomplex of the spliceosome |
| 6325107 | Hypothetical ORF |
| 6325110 | Subunit of a heterodimeric peroxisomal ATP-binding cassette transporter complex (Pxa1p-Pxa2p), required for import of long-chain fatty acids into peroxisomes; similarity to human adrenoleukodystrophy transporter and ALD-related proteins |
| 6325116 | Hypothetical ORF |
| 6325117 | Mitogen-activated kinase kinase involved in protein kinase C signaling pathway that controls cell integrity; upon activation by Bck1p phosphorylates downstream target, Slt2p; functionally redundant with Mkk1p |
| 6325125 | Mitochondrial membrane protein required for assembly of active cytochrome c oxidase, probably involved in insertion of Cu(B) and magnesium |
| 6325132 | Karyopherin with a role in the assembly or export of 60S ribosomal subunits |
| 6325138 | Putative ATP-dependent RNA helicase of the DEAD-box protein family; mutants show reduced stability of the 40S ribosomal subunit scanning through 5' untranslated regions of mRNAs |
| 6325144 | Putative dehydrogenase |
| 50593504 | Hypothetical ORF |
| 6325151 | HSP70 family member, highly homologous to Ssa1p and Sse2p |
| 6325153 | Mitochondrial aspartyl-tRNA synthetase, required for acylation of aspartyl-tRNA; yeast and bacterial aspartyl-, asparaginyl-, and lysyl-tRNA synthetases contain regions with high sequence similarity, suggesting a common ancestral gene |
| 6325160 | Mitochondrial tyrosyl-tRNA synthetase |
| 6325162 | Hypothetical ORF |
| 6325164 | Putative GTPase that associates with free 60S ribosomal subunits in the nucleolus and is required for 60S ribosomal subunit biogenesis; constituent of 66S pre-ribosomal particles; member of the ODN family of nucleolar G-proteins |
| 6325166 | Cytosolic and mitochondrial glutathione oxidoreductase, converts oxidized glutathione to reduced glutathione |
| 6325169 | Putative aryl alcohol dehydrogenase; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance |
| 6325175 | Essential abundant protein involved in regulation of transcription, removes Spt15p (TBP) from DNA via its C-terminal ATPase activity, forms a complex with TBP that binds TATA DNA with high affinity but with altered specificity |
| 6325183 | Putative ATPase of the CDC48/PAS1/SEC18 (AAA) family, localized to the cortex of mother cells but not to daughter cells |
| 6325188 | Geranylgeranyl diphosphate synthase, increases the intracellular pool of geranylgeranyl diphosphate, suppressor of bet2 mutation that causes defective geranylgeranylation of small GTP-binding proteins that mediate vesicular traffic |
| 6325194 | Constituent of the mitochondrial inner membrane presequence translocase (TIM23 complex); may promote binding of incoming precursor proteins to the intermembrane space domain of Tom22p during translocation |
| 6325199 | Plasma membrane weak-acid-inducible ATP-binding cassette (ABC) transporter, required for weak organic acid resistance, strongly induced by sorbate and benzoate, regulated by War1p, mutants exhibit sorbate hypersensitivity |
| 6325215 | Component of RNA polymerase II holoenzyme, involved in RNA pol II carboxy-terminal domain phosphorylation |
| 6325217 | Mitochondrial isoleucyl-tRNA synthetase, null mutant is deficient in respiratory growth |
| 6325221 | Plasma membrane H+-ATPase, isoform of Pma1p, involved in pumping protons out of the cell; regulator of cytoplasmic pH and plasma membrane potential |
| 6325228 | ATP-dependent RNA helicase, component of the mitochondrial degradosome along with the RNase Msu1p; the degradosome associates with the ribosome and mediates turnover of aberrant or unprocessed RNAs |
| 6325231 | multicopy suppressor of snf3 and grr1 mutants; serine/threonine protein kinase homologous to Ran1p |
| 6325235 | Single-stranded DNA endonuclease (with Rad10p), cleaves single-stranded DNA during nucleotide excision repair and double-strand break repair; subunit of Nucleotide Excision Repair Factor 1 (NEF1); homolog of human ERCC1 protein |
| 6325240 | Putative S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family |
| 6325242 | Cytoplasmic member of the silencing information regulator 2 (Sir2) family of NAD(+)-dependent protein deacetylases; modulates nucleolar (rDNA) and telomeric silencing; possesses NAD(+)-dependent histone deacetylase activity in vitro |
| 6325248 | Hypothetical ORF |
| 6325249 | Conserved nuclear protein required to establish sister-chromatid pairing during S-phase, probable DNA helicase with similarity to human BACH1, which associates with tumor suppressor BRCA1; associates with acetyltransferase Ctf7p |
| 6325251 | Vacuolar membrane protein that transits through the biosynthetic vacuolar protein sorting pathway, involved in sphingolipid metabolism; glycoprotein homologous to human Niemann Pick C1 (NPC) protein |
| 6325254 | Protein that acts together with Uba3p to activate Rub1p before its conjugation to proteins (neddylation), which may play a role in protein degradation |
| 6325260 | Hypothetical ORF |
| 6325261 | Hypothetical ORF |
| 6325263 | 2-methylisocitrate lyase of the mitochondrial matrix, functions in the methylcitrate cycle to catalyze the conversion of 2-methylisocitrate to succinate and pyruvate; ICL2 transcription is repressed by glucose and induced by ethanol |
| 6325267 | RNA polymerase I subunit A135 |
| 6325276 | Essential helicase component of heterohexameric MCM2-7 complexes which bind pre-replication complexes on DNA and melt the DNA prior to replication; accumulates in the nucleus in G1; homolog of S. pombe Cdc21p |
| 6325281 | Mitochondrial inner membrane protease of the AAA family, responsible for degradation of unfolded or misfolded mitochondrial gene products; mutation causes an elevated rate of mitochondrial turnover |
| 6325286 | Gamma-adaptin, large subunit of the clathrin-associated protein (AP) complex |
| 6325293 | vacuolar ATPase V1 domain subunit H (54 kDa) |
| 6325296 | Flavin-linked sulfhydryl oxidase localized to the endoplasmic reticulum lumen, involved in disulfide bond formation within the ER |
| 6325298 | eIF5 mediates hydrolysis of eIF2-GTP (SUI2,SUI3,GCD11) at start codons; Translation initiation factor eIF-5 |
| 6325305 | Protein with a potential role in DNA replication; displays synthetic lethal genetic interaction with the pol3-13 allele of POL3, which encodes DNA polymerase delta |
| 6325311 | Mitogen-activated protein kinase required for spore morphogenesis that is expressed as a middle sporulation-specific gene |
| 6325325 | Putative class I histone deacetylase (HDAC) with sequence similarity to Hda1p, Rpd3p, Hos2p, and Hos3p; deletion results in increased histone acetylation at rDNA repeats; interacts with the Tup1p-Ssn6p corepressor complex |
| 6325368 | Ser/Thr kinase involved in late nuclear division, one of the mitotic exit network (MEN) proteins; necessary for the execution of cytokinesis |
| 6325369 | Essential conserved protein that associates with 35S precursor rRNA and is required for its initial processing at the A(0)-A(2) cleavage sites, shows partial nucleolar localization, contains five consensus RNA-binding domains |
| 6325376 | Involved in mitotic induction; G(sub)2-specific B-type cyclin |
| 6325377 | B-type cyclin with a role in DNA replication during S phase; has an additional functional role in formation of mitotic spindles along with Clb3p and Clb4p |
| 6325379 | Haploid specific endoprotease that performs one of two N-terminal cleavages during maturation of a-factor mating pheromone; required for axial budding pattern of haploid cells |
| 6325384 | Hypothetical ORF |
| 6325386 | Protein containing an Lsm domain, may bind RNA and have a role in RNA processing; overproduction suppresses a null mutation in CHC1, which encodes the heavy chain of clathrin |
| 6325390 | Protein that interacts with Spt6p and copurifies with Spt5p and RNA polymerase II, probable transcriptional elongation factor; metazoan homologs contain an acidic N terminus; mutations in the gene confer an Spt- phenotype |
| 6325394 | Protein involved in pre-rRNA processing, associated with U3 snRNP; component of small ribosomal subunit (SSU) processosome; ortholog of the human U3-55k protein |
| 7839207 | TyB Gag-Pol protein; proteolytically processed to make the Gag, RT, PR, and IN proteins that are required for retrotransposition |
| 6325399 | Minus-end-directed microtubule motor that functions in mitosis and meiosis, localizes to the spindle pole body and localization is dependent on functional Cik1p, required for nuclear fusion during mating; potential Cdc28p substrate |
| 6325402 | Nucleolar protein, forms a complex with Nop14p that mediates maturation and nuclear export of 40S ribosomal subunits |
| 6325414 | Polyamine transport protein |
| 7839211 | TyB Gag-Pol protein; proteolytically processed to make the Gag, RT, PR, and IN proteins that are required for retrotransposition |
| 6325419 | CDC28/cdc2 related protein kinase |
| 6325425 | 3'-phosphoadenylsulfate reductase, reduces 3'-phosphoadenylyl sulfate to adenosine-3',5'-bisphosphate and free sulfite using reduced thioredoxin as cosubstrate, involved in sulfate assimilation and methionine metabolism |
| 6325431 | Defective in vacuolar protein sorting; homologous to mouse SKD1 and to human hVPS4; AAA-type ATPase |
| 6325438 | Nuclear protein that acts as a heterodimer with Uba2p to activate Smt3p (SUMO) before its conjugation to proteins (sumoylation), which may play a role in protein targeting; essential for viability |
| 6325442 | Glycogen debranching enzyme containing glucanotranferase and alpha-1,6-amyloglucosidase activities, required for glycogen degradation |
| 6325452 | Oligopeptide transporter; member of the OPT family, with potential orthologs in S. pombe and C. albicans |
| 6325455 | Member of drug-resistance protein family; multicopy suppressor of gal11 null mutation |
| 6325459 | Arsenite transporter of the plasma membrane, required for resistance to arsenic compounds; transcription is activated by Arr1p in the presence of arsenite |
| 6325462 | subtelomerically-encoded DNA helicase |
| 6324416 | Hypothetical ORF |
| 6324418 | ORF |
| 6324427 | Component of the Paf1p complex, which is a large complex that binds to and modulates the activity of RNA polymerase II and is required for expression of a subset of genes, including cyclin genes; contains TPR repeats |
| 6324440 | Putative 1,3-beta-glucanosyltransferase, has similarity to Gas1p; localizes to the cell wall |
| 6324444 | Yeast homologue of mammalian Glycogen Synthase Kinase 3 |
| 6324446 | Cytoplasmic malate dehydrogenase, catalyzes interconversion of malate and oxaloacetate; involved in gluconeogenesis and glyoxylate cycle |
| 6324450 | Divalent metal ion transporter |
| 6324459 | Serine/threonine protein kinase with similarity to Ste20p and Cla4p |
| 6324460 | GTPase-activating protein of the Ras superfamily that acts primarily on Sec4p, localizes to the bud site and bud tip, has similarity to Msb3p; msb3 msb4 double mutation causes defects in secretion and actin organization |
| 6324467 | cell wall integrity and stress response component 3; Putative integral membrane protein containing novel cysteine motif. Similarity to SLG1 (WSC1), WSC2 and WSC4 |
| 7839197 | TyB Gag-Pol protein; proteolytically processed to make the Gag, RT, PR, and IN proteins that are required for retrotransposition |
| 37362691 | Myo-inositol transporter with strong similarity to the major myo-inositol transporter Itr1p, member of the sugar transporter superfamily; expressed constitutively |
| 6324472 | Serine/threonine protein kinase involved in sphingolipid-mediated signaling pathway that controls endocytosis; activates Ypk1p and Ykr2p, components of signaling cascade required for maintenance of cell wall integrity; redundant with Pkh1p |
| 6324477 | Mitochondrial inner membrane localized ATP-dependent DNA helicase, required for the maintenance of the mitochondrial genome; not required for mitochondrial transcription |
| 6324482 | Protein that forms heterodimers, with Msh3p and Msh6p, that bind to DNA mismatches to initiate the mismatch repair process; contains a Walker ATP-binding motif required for repair activity; Msh2p-Msh6p binds to and hydrolyzes ATP |
| 6324486 | Alcohol dehydrogenase, fermentative isozyme active as homo- or heterotetramers; required for the reduction of acetaldehyde to ethanol, the last step in the glycolytic pathway |
| 6324493 | Putative RNA exonuclease possibly involved in pre-rRNA processing and ribosome assembly |
| 6324498 | Hypothetical ORF |
| 6324512 | Protein required for normal mitochondrial morphology, has similarity to hemolysins |
| 6324513 | NAD-dependent glycerol 3-phosphate dehydrogenase, homolog of Gpd1p, expression is controlled by an oxygen-independent signaling pathway required to regulate metabolism under anoxic conditions; located in cytosol and mitochondria |
| 6324515 | Hypothetical ORF |
| 6324517 | Hydroxymethylpyrimidine phosphate kinase, involved in the last steps in thiamine biosynthesis; member of a gene family with THI21 and THI22; functionally redundant with Thi21p |
| 6324521 | S-adenosylmethionine decarboxylase |
| 6324530 | DNA N-glycosylase and apurinic/apyrimidinic (AP) lyase involved in base excision repair, localizes to the nucleus |
| 6324535 | 20S proteasome alpha-type subunit |
| 6324539 | Structural maintenance of chromosomes (SMC) protein, interacts with Rhc18p and Nse1p to form a large complex; S. pombe homolog forms a heterodimer with S. pombe Rad18p that is involved in DNA repair |
| 6324540 | Mitochondrial glutamyl-tRNA synthetase, encoded by a nuclear gene |
| 6324550 | Mitochondrial translation initiation factor 2 |
| 6324552 | Nucleolar exosome component, involved in rRNA processing and RNA degradation, binds Gsp1p/Ran and enhances the GEF activity of Srm1p, implicated in mitotic control, homologous to the E. coli RNase R of the RNase II family |
| 6324553 | Tryptophan permease, high affinity |
| 6324557 | Calmodulin-dependent protein kinase |
| 6324571 | DHHC-CRD protein |
| 6324574 | Exonuclease component of the nuclear exosome; contributes to the quality-control system that retains and degrades aberrant mRNAs in the nucleus |
| 6324576 | subtilisin-like protease III |
| 6324578 | DNA ligase required for nonhomologous end-joining (NHEJ), forms stable heterodimer with required cofactor Lif1p, catalyzes DNA ligation as part of a complex with Lif1p and Nej1p; involved in meiosis, not essential for vegetative growth |
| 6324580 | Glutamine-rich cytoplasmic protein of unknown function, contains tetratricopeptide (TPR) repeats, which often mediate protein-protein interactions; conserved in human and C. elegans |
| 6324581 | Protein involved in cell wall integrity and stress response |
| 6324583 | Cell wall mannoprotein of the Srp1p/Tip1p family of serine-alanine-rich proteins; expressed under anaerobic conditions and required for anaerobic growth; transcription is also induced by cold shock |
| 6324585 | Transporter of the ATP-binding cassette family, involved in uptake of sterols and anaerobic growth |
| 6324607 | 5'-3' exonuclease and flap-endonuclease involved in recombination, double-strand break repair and DNA mismatch repair; member of the Rad2p nuclease family, with conserved N and I nuclease domains |
| 6324610 | Target membrane receptor (t-SNARE) for vesicular intermediates traveling between the Golgi apparatus and the vacuole; controls entry of biosynthetic, endocytic, and retrograde traffic into the prevacuolar compartment; syntaxin |
| 6324612 | Non-essential transcriptional corepressor involved in the cell cycle-regulated transcription of histone H2A, H2B, H3, and H4 genes; recruits Swi-Snf complexes to histone gene promoters; promotes heterochromatic gene silencing with Asf1p |
| 6324620 | Cytoplasmic ATP-dependent RNA helicase of the DEAD-box family involved in mRNA export from the nucleus |
| 6324622 | Nuclear 5' to 3' single-stranded RNA exonuclease, involved in RNA metabolism, including rRNA and snRNA processing as well as mRNA transcription termination |
| 6324631 | Probable cochaperone, regulates activity of Cyr1p (adenylyl cyclase); involved in assembly of the kinetochore complex, associates with the SCF (Skp1p/Cdc53p/F box protein) ubiquitin ligase complex |
| 6324638 | Yeast homolog of mammalian Ing1; histone acetyltransferase complex component |
| 6324644 | Cis-golgi GTPase-activating protein (GAP) for the Rab family members Ypt1p (in vivo) and for Ypt1p, Sec4p, Ypt7p, and Ypt51p (in vitro); involved in vesicle docking and fusion |
| 6324645 | Hypothetical ORF |
| 6324655 | Protein of unknown function, localizes to lipid particles; potential Cdc28p substrate |
| 6324664 | Mitochondrially localized type 2C protein phosphatase; contains Mg2+/Mn2+-dependent casein phosphatase activity in vitro but in vivo substrates are unknown |
| 6324665 | Hypothetical ORF |
| 6324667 | Hypothetical ORF |
| 6324675 | GTPase involved in G-protein signaling in the adenylate cyclase activating pathway, plays a role in cell proliferation; localized to the plasma membrane; homolog of mammalian RAS proto-oncogenes |
| 6324682 | Alpha-isopropylmalate synthase II (2-isopropylmalate synthase), catalyzes the first step in the leucine biosynthesis pathway; the minor isozyme, responsible for the residual alpha-IPMS activity detected in a leu4 null mutant |
| 6324683 | Phosphatidylinositol 4,5-bisphosphate 5-phosphatase, synaptojanin-like protein with an N-terminal Sac1 domain, plays a role in a TGN (trans Golgi network)-to-early endosome pathway; hyperosmotic stress causes translocation to actin patches |
| 6324687 | Zinc-finger transcription factor, involved in induction of CLN3 transcription in response to glucose; genetic and physical interactions indicate a possible role in mitochondrial transcription or genome maintenance |
| 6324690 | RNA polymerase III subunit C160, part of core enzyme; similar to bacterial beta-prime subunit |
| 6324691 | One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; recruited to the GAL1-10 promoter region upon induction of transcription |
| 6324693 | Essential serine kinase involved in cell cycle progression and processing of the 20S pre-rRNA into mature 18S rRNA |
| 6324707 | Elongation factor 2 (EF-2), also encoded by EFT2; catalyzes ribosomal translocation during protein synthesis; contains diphthamide, the unique posttranslationally modified histidine residue specifically ADP-ribosylated by diphtheria toxin |
| 7839199 | TyB Gag-Pol protein; proteolytically processed to make the Gag, RT, PR, and IN proteins that are required for retrotransposition |
| 6324720 | Essential nucleolar protein required for pre-18S rRNA processing, interacts with Dim1p, an 18S rRNA dimethyltransferase, and also with Nob1p, which is involved in proteasome biogenesis; contains a KH domain |
| 6324725 | RNA polymerase II second largest subunit B150, part of central core; similar to bacterial beta subunit |
| 6324727 | Short-lived membrane ABC (ATP-binding cassette) transporter, actively exports various drugs, expression regulated by Pdr1p; also involved in steroid transport, cation resistance, and cellular detoxification during exponential growth |
| 6324739 | Synthetic Enhancement with YOP1 |
| 6324742 | Glutamine tRNA synthetase, monomeric class I tRNA synthetase that catalyzes the specific glutaminylation of tRNA(Glu); N-terminal domain proposed to be involved in enzyme-tRNA interactions |
| 6324759 | GTP binding protein (mammalian Ranp homolog) involved in the maintenance of nuclear organization, RNA processing and transport; interacts with Kap121p, Kap123p and Pdr6p (karyophilin betas); Gsp1p homolog that is not required for viability |
| 6324765 | Member of the SWI/SNF family of DNA-dependent ATPases, plays a role in antagonizing silencing during mating-type switching, contains an N-terminal domain that interacts with Sir4p and a C-terminal SNF2 domain |
| 6324766 | Hypothetical ORF |
| 7839201 | TyB Gag-Pol protein; proteolytically processed to make the Gag, RT, PR, and IN proteins that are required for retrotransposition |
| 6324770 | Protein involved in biosynthesis of the coenzyme lipoic acid, has similarity to E. coli lipoic acid synthase |
| 6324778 | ATP-dependent DEAD (Asp-Glu-Ala-Asp)-box RNA helicase, required for translation initiation of all yeast mRNAs; mutations in human DEAD-box DBY are a frequent cause of male infertility |
| 6324781 | Second-largest subunit of RNA polymerase III, which is responsible for the transcription of tRNA and 5S RNA genes, and other low molecular weight RNAs |
| 6324785 | Mitochondrial GTPase related to dynamin, present in a complex containing Ugo1p and Fzo1p; required for normal morphology of cristae and for stability of Tim11p; homolog of human OPA1 involved in autosomal dominant optic atrophy |
| 6324791 | Subunit of heteropentameric Replication factor C (RF-C), which is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor for DNA polymerases delta and epsilon |
| 6324793 | Dipeptidyl aminopeptidase, Golgi integral membrane protein that cleaves on the carboxyl side of repeating -X-Ala- sequences, required for maturation of alpha factor, transcription is induced by a-factor |
| 6324805 | Mitogen-activated kinase kinase involved in protein kinase C signaling pathway that controls cell integrity; upon activation by Bck1p phosphorylates downstream target, Slt2p; functionally redundant with Mkk2p |
| 6324807 | Nonessential protein kinase with unknown cellular role |
| 6324810 | Dihydrofolate reductase, part of the dTTP biosynthetic pathway, involved in folate metabolism, possibly required for mitochondrial function |
| 6324815 | Folylpolyglutamate synthetase, catalyzes extension of the glutamate chains of the folate coenzymes, required for methionine synthesis and for maintenance of mitochondrial DNA, present in both the cytoplasm and mitochondria |
| 6324818 | Histone acetyltransferase catalytic subunit of the native multisubunit complex (NuA4) that acetylates four, conserved internal lysines of histone H4 N-terminal tail; required for cell cycle progression |
| 6324820 | Protein with similarity to oxidoreductases, found in lipid particles; required for replication of Brome mosaic virus in S. cerevisiae, which is a model system for studying replication of positive-strand RNA viruses in their natural hosts |
| 6324833 | One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; required for spindle pole body duplication; localized mainly to the nucleus throughout the cell cycle |
| 6324844 | Subunit of vacuolar-ATPase V0 domain, one of two isoforms (Vph1p and Stv1p); Vph1p is located in V-ATPase complexes of the vacuole while Stv1p is located in V-ATPase complexes of the Golgi and endosomes |
| 6324847 | Polyamine transport protein |
| 6324864 | Catalytic subunit of the 11-subunit SWI/SNF chromatin remodeling complex involved in transcriptional regulation; contains DNA-stimulated ATPase activity; functions interdependently in transcriptional activation with Snf5p and Snf6p |
| 6324865 | Hypothetical ORF |
| 6324879 | Member of the imitation-switch (ISWI) class of ATP-dependent chromatin remodeling complexes; ATPase component that, with Itc1p, forms a complex required for repression of a-specific genes, INO1, and early meiotic genes during mitotic growth |
| 6324886 | Protein involved in pre-rRNA processing, 18S rRNA synthesis, and snoRNA synthesis; component of the small subunit processome complex, which is required for processing of pre-18S rRNA |
| 6324893 | Long chain fatty acyl-CoA synthetase with a preference for C12 |
| 6324899 | Gamma-glutamyl phosphate reductase, catalyzes the second step in proline biosynthesis |
| 6324902 | One of two type V myosins, involved in polarized distribution of mitochondria; required for mitochondrion and vacuole inheritance and nuclear spindle orientation; moves multiple cargo |
| 6324904 | ABC (ATP-binding cassette) membrane pump involved in the pleiotropic drug resistance network, regulated by Pdr1p and Pdr3p, similar to Pdr5p |
| 6324911 | Cytoplasmic alanyl-tRNA synthetase, required for protein synthesis; point mutation (cdc64-1 allele) causes cell cycle arrest at G1; lethality of null mutation is functionally complemented by human homolog |
| 6324917 | RNA polymerase I subunit; largest subunit of RNA polymerase I |
| 20336770 | TyB Gag-Pol protein; proteolytically processed to make the Gag, RT, PR, and IN proteins that are required for retrotransposition |
| 6324924 | Proline permease, required for high-affinity transport of proline; also transports the toxic proline analog azetidine-2-carboxylate (AzC); PUT4 transcription is repressed in ammonia-grown cells |
| 6324927 | Meiosis-specific serine/threonine protein kinase, functions in meiotic checkpoint, phosphorylates Red1p, interacts with Hop1p; required for meiotic recombination and normal spore viability |
| 6324937 | Subunit of the core complex of translation initiation factor 3(eIF3), essential for translation; part of a subcomplex (Prt1p-Rpg1p-Nip1p) that stimulates binding of mRNA and tRNA(i)Met to ribosomes |
| 6324962 | DNA photolyase involved in photoreactivation, repairs pyrimidine dimers in the presence of visible light; induced by DNA damage; regulated by transcriptional repressor Rph1p |
| 6324964 | NAD(+)-dependent formate dehydrogenase, may protect cells from exogenous formate |
